潘氏细胞为小肠干细胞提供微环境信号因子研究进展  

Microenvironment signaling factors of intestinal stem cells provided by Paneth cells

作　　者：李艳丽 郭煜晖[1] 刘雨 熊正国[1] 张长城[1] 顿耀艳[1] LI Yanli;GUO Yuhui;LIU Yu;XIONG Zhengguo;ZHANG Changcheng;DUN Yaoyan(Medical College,China Three Gorges University,Yichang 443002,China)

机构地区：[1]三峡大学医学院,宜昌443002

出　　处：《生物学杂志》2021年第5期105-109,共5页Journal of Biology

基　　金：国家自然科学基金项目(81873349,81503423,81403307)。

摘　　要：潘氏细胞是重要的微环境信号分子提供者,可为小肠干细胞(intestinal stem cells,ISCs)提供Wnt、Notch、EGF、mTORC1等相关信号因子,维持干细胞的增殖和分化平衡。对潘氏细胞提供ISCs微环境信号因子,以及潘氏细胞相关信号因子变化导致的小肠上皮稳态失调进行概述,旨在为潘氏细胞和ISCs相互作用的研究提供思考,为相关小肠上皮稳态失调提供新的治疗思路。The microenvironment composed of cells adjacent to intestinal stem cells(ISCs)is key to the function of ISCs by providing a variety of essential signaling factors that regulate important signaling pathways for proliferation and differentiation in ISCs.Paneth cells are important providers of ISCs microenvironmental signaling molecules,and they can provide Wnt,Notch,EGF,mTORC1 and other related signaling factors for ISCs to maintain the balance of proliferation and differentiation.The signaling factors secreted by the Paneth cell are summarized here,to provide some ideas for the study of interaction between Paneth cells and ISCs,and the treatment of some intestinal epithelial homeostasis disorders.

关 键 词：潘氏细胞 微环境 小肠干细胞 信号因子 小肠上皮稳态 

分 类 号：Q25[生物学—细胞生物学]