腹透引流液中IL-6及NGAL检测对腹透相关性腹膜炎的诊断价值  

Diagnostic Value of Peritoneal Dialysisdrainage Fluid IL-6 and NGAL Inperitoneal Dialysis-Associated Peritonitis

作　　者：庄乙君 陈文[1] 云曼丽 钟业腾 林叶[1] 李军[1] 李飞 汪水连 韩淑苗 ZHUANG Yijun;CHEN Wen;YUN Manli(The Second Affiliated Hospital of Hainan Medical College, Hainan Haikou 570311, China)

机构地区：[1]海南医学院第二附属医院,海南海口570311 [2]海南医学院研究生学院,海南海口570100

出　　处：《河北医学》2021年第10期1675-1679,共5页Hebei Medicine

基　　金：海南省高等学校科学研究资助项目,(编号:HnKy2019ZD-33)。

摘　　要：目的:探讨腹透引流液中白介素-6(IL-6)及中性粒细胞明胶酶相关脂质运载蛋白(NGAL)检测对腹透相关性腹膜炎(PDAP)的诊断价值。方法:选取2019年1月至2020年9月在我院肾内科病房住院接受腹膜透析(PD)的患者120例为研究对象,根据患者是否出现PDAP分为PDAP组、非PDAP组,比较两组腹透引流液中IL-6及NGAL水平,并分析以上指标在PDAP中的诊断价值。结果:经跟踪随访发现,120例患者中有55例患者出现PDAP;PDAP组引流液IL-6、NGAL、WBC水平及透析龄均显著高于非PDAP组(P<0.05);引流液IL-6、引流液NGAL、引流液WBC、透析龄是导致PDAP发生的独立危险因素;IL-6、NGAL单项检测在PDAP中均具有较高的诊断价值。结论:引流液中IL-6、NGAL影响PDAP发生的独立危险因素,可为PDAP诊断提供有效依据。Objective:To investigate the diagnostic value of peritoneal dialysis(PD)drainage fluid interleukin-6(IL-6)and neutrophil gelatinase-associated lipocalin(NGAL)in peritoneal dialysis-associated peritonitis(PDAP).Methods:A total of 120 patients hospitalized in the nephrology department and undergoing PD in the hospital between January 2019 and September 2020 were selected as study objects.According to the presence or absence of PDAP,the patients were divided into PDAP group and non-PDAP group.The levels of drainage fluid IL-6 and NGAL in the two groups were compared,and their diagnostic valuein PDAP was analyzed.Results:Follow-up revealed that 55 of the 120 patients developed PDAP.The drainage fluid IL-6,NGAL and WBC,and dialysis age of the PDAP group were significantly higher or longer than those of the non-PDAP group(P<0.05).Drainage fluid IL-6,NGAL and WBC,and dialysis age were independent risk factors for PDAP.Both IL-6 and NGAL single detection were of high value in the diagnosis of PDAP.Conclusion:IL-6 and NGAL in drainage fluid are independent risk factors for PDAP,which provides an effective basis for the diagnosis of PDAP.

关 键 词：腹透相关性腹膜炎 腹透引流液 IL-6 NGAL 诊断价值 

分 类 号：R69[医药卫生—泌尿科学]