丹参酮对过敏性紫癜患儿Th1/Th2型细胞因子及疗效的影响  

Effect of Tanshinone on Th1/Th2 Cytokines in Children with Henoch-Schonlein Purpura and Curative Effect of Tanshinone

作　　者：齐海花[1] 黄占强[1] 何磊[1] 刘利君[1] 牛艳东[1] 于淑萍[1] 段昕所[1] QI Haihua;HUANG Zhanqiang;HE Lei(Affiliated Hospital of Chengde Medical University, Hebei Chengde 067000, China)

机构地区：[1]承德医学院附属医院,河北承德067000

出　　处：《河北医学》2021年第10期1716-1719,共4页Hebei Medicine

基　　金：河北省承德市科技计划支撑项目,(编号:201701A044)。

摘　　要：目的:探讨丹参酮对过敏性紫癜患儿Th1/Th2型细胞因子及疗效的影响。方法:选取于我院确诊为过敏性紫癜患儿80例,随机分为对照组和观察组,每组40例,两组均常规给予改善血管脆性以及抗过敏等对症治疗,观察组在上述治疗同时加用丹参酮胶囊治疗2周,检测对照组及观察组患儿治疗前、后外周血INF-γ、IL-2、IL-6、IL-10水平变化,并进行临床疗效评价。结果:两组患儿治疗前INF-γ、IL-2、IL-6、IL-10水平无统计学差异(P>0.05)。治疗后,两组患儿外周血INF-γ、IL-2水平较前升高,IL-6、IL-10水平较前下降(P<0.05)。观察组外周血INF-γ、IL-2水平升高幅度优于对照组(P<0.05),观察组外周血IL-10水平下降幅度优于对照组(P<0.05),观察组外周血IL-6下降幅度较对照组无差异(P>0.05)。观察组有效率明显高于对照组,有统计学差异(P<0.05)。结论:丹参酮辅助治疗儿童过敏性紫癜疗具有一定临床疗效,其机制可能通过影响外周血细胞因子水平以纠正机体Th1/Th2免疫失衡而起作用。Objective:To investigate the effect of tanshinone on Th1/Th2 cytokines and therapeutic effect in children with Henoch-Schonlein purpura.Methods:Eighty patients diagnosed with Henoch-Schonlein purpura in our hospital were selected and randomly divided into control group and observation group with 40 cases in each group.Both groups were routinely given symptomatic treatments such as anti-allergic and improving vascular fragility.The group of observation was treated with tanshinone for 2 weeks on the basis of routine treatment.Changes in the levels of INF-γ、IL-2、IL-6、IL-10 in the peripheral blood of the two groups of children before and after therapy was observeed,and the clinical efficacy was evaluated.Results:There was no significant difference in the levels of INF-γ、IL-2、IL-6 and IL-10 between the control and observation groups before treatment(P>0.05).After treatment,the levels of INF-γand IL-2 in the peripheral blood of the two groups were higher than before,and the levels of IL-6 and IL-10 were lower than before(P<0.05).The increase in peripheral blood INF-γand IL-2 levels in the observation group was better than that in the control group(P<0.05),and the decrease in peripheral blood IL-10 levels in the observation group was better than that in the control group(P<0.05).The decrease of IL-6 in peripheral blood of the observation group was no different than that of the control group(P>0.05).The effective rate of the observation group was significantly higher than that of the control group,and there was a statistical difference(P<0.05).Conclusion:Tanshinone has a certain clinical effect in the treatment of allergic purpura in children,and its mechanism may act by influencing the levels of peripheral blood cytokines to correct the body's Th1/Th2 immune imbalance.

关 键 词：丹参酮 过敏性紫癜 干扰素-Γ 白介素-2 白介素-6 白介素-10 

分 类 号：R725.5[医药卫生—儿科]