全国住院输血新生儿疾病谱前五名疾病的血液检测指标分析  

Analysis of Blood Test Indexes of the First Five Diseases of Hospitalized Newborn with Blood Transfusion in China

作　　者：马婷[1] 孙杨[2] 邢莉莉 牛佳萌 王秋实[4] 杨江存[1] MA Ting;SUN Yang;XING Li-li(Department of Transfusion Medicine,Shaanxi Provincial People's Hospital,Xi'an 710068)

机构地区：[1]陕西省人民医院输血科,710068 [2]陕西省人民医院数据中心,710068 [3]西安医学院 [4]中国医科大学附属盛京医院

出　　处：《临床输血与检验》2021年第5期593-599,共7页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：陕西省科技成果转移与推广计划-获奖成果转化项目(No.2019CGHJ-09,2020CGH-029)资助。

摘　　要：目的通过分析全国住院输血新生儿疾病谱及前五名疾病患儿入院后进行干预治疗前的血液检测指标,比较不同疾病血液指标特征,为新生儿精准医治提供数据支持。方法采用多中心回顾性调查,收集2017年1月1日~2018年6月30日全国46家三级公立医院接受输血治疗的5669例住院新生儿相关诊疗数据,按照国际疾病分类编码(ICD-10)的疾病主要诊断进行统计分析,获得住院输血新生儿疾病谱。对入院后干预治疗前患儿的血常规指标、肝功能指标、凝血功能及血气分析指标进行分析,获得不同疾病干预前血液检测指标的区间范围。结果导致新生儿住院输血前五名疾病依次为早产儿(25.44%)、新生儿肺炎(15.82%)、新生儿高胆红素血症(10.65%)、新生儿溶血病(6.40%)、新生儿呼吸窘迫综合征(6.07%)。前五名疾病各组间的血常规指标、肝功能指标、凝血功能及血气分析指标进行统计分析检验结果差异均有统计学意义(P<0.05)。新生儿肺炎和新生儿呼吸窘迫综合征患儿的血常规指标(RBC、HGB、HCT、WBC)、凝血指标(PT、APTT、INR)、肝功能指标(ALT、TBIL、TP、ALB)、血气指标(PO_(2)及SO_(2))有统计学差异;新生儿高胆红素血症和新生儿溶血病患儿血常规指标(RBC、HGB、HCT、WBC)、凝血功能指标(APTT、FIB)、肝功能指标(TBIL、TP)、血气指标(PH、PO_(2)、HCT)有统计学差异。结论我国输血新生儿疾病主要以早产儿、呼吸系统疾病、高胆红素血症为主,不同疾病血液检测指标存在差异,提示针对新生儿诊治要根据不同疾病进行精准化个体性诊疗。Objective To compare the characteristics of blood indexes of different diseases by analyzing the disease spectrum of hospitalized blood transfusion newborns in China and the blood test indexes of the top five diseases before admission without intervention treatment,so as to provide data support for accurate treatment of newborns.Methods A multicenter retrospective survey method was used to collect the relevant diagnosis and treatment data of 5669 hospitalized newborns who received blood transfusion treatment in 46 tertiary public hospitals in China from January 1,2017 to June 30,2018.Statistical analysis was carried out according to the main disease diagnosis of the International Classification of Diseases Code(ICD-10)to obtain the disease spectrum of hospitalized newborns with blood transfusion.The routine blood test indexes,liver function indexes,blood coagulation function and blood gas indexes of the newborns after admission before treatment and intervention were analyzed to obtain the range of blood test indexes for different diseases before intervention.Results The first five diseases were premature infants(25.44%),neonatal pneumonia(15.82%),neonatal hyperbilirubinemia(10.65%),neonatal hemolytic disease(6.40%),and neonatal respiratory distress syndrome(6.07%).The routine blood test indexes,liver function indexes,coagulation function and blood gas indexes of the first five diseases were statistically significant(P<0.05).The routine blood test indexes(RBC,HGB,HCT,WBC),coagulation indexes(PT,APTT,INR),liver function indexes(ALT,TBIL,TP,ALB),blood gas(PO_(2)and SO_(2))of neonatal pneumonia and neonatal respiratory distress syndrome were statistically significant.The routine blood test(RBC,HGB,HCT,WBC),coagulation function(APTT,FIB),liver function(TBIL,TP),blood gas(PH,PO_(2),HCT)of neonatal hyperbilirubinemia and neonatal hemolytic disease were statistically significant.Conclusion Premature infants,respiratory diseases and hyperbilirubinemia are the main diseases of neonatal blood transfusion in China,and there

关 键 词：新生儿 疾病谱 血液检查 输血 

分 类 号：R722.1[医药卫生—儿科]