氮丙啶衍生物与环状酸酐共聚合成聚酯酰胺  

Copolymerization of Aziridine Derivatives and Cyclic Anhydrides to Form Poly(ester amide)s

作　　者：刘文静[1] 乐天俊 任伟民[1] Wen-jing Liu;Tian-jun Yue;Wei-min Ren(State Key Laboratory of Fine Chemicals,Dalian University of Technology,Dalian 116024)

机构地区：[1]精细化工国家重点实验室大连理工大学化工学院,大连116024

出　　处：《高分子学报》2021年第7期717-722,I0002,共7页Acta Polymerica Sinica

基　　金：国家自然科学基金(基金号21722402)资助项目.

摘　　要：开发高效合成聚酯酰胺的方法一直是该领域研究的重点和难点.本文发展了一种以有机碱为催化剂,以苄醇为引发剂,先通过易合成的氮丙啶衍生物与环状酸酐反应得到N-取代的共聚物,再通过氧化法由K_(2)S_(2)O_(8)/Na_(2)HPO_(4)体系脱去氮原子上取代基从而合成聚酯酰胺的新方法.通过该方法合成了9种不同结构的聚酯酰胺,为其在生物医学领域的应用提供了新的选择.Poly(ester amide)s(PEAs)are important synthetic polymeric materials.The excellent biodegradability and mechanical properties make the synthesis of such kinds polymers a research hotspot in the field of polymer chemistry.Herein,we report a novel strategy for accessing PEAs via the alternating copolymerization of easily synthesized aziridine derivatives and cyclic anhydrides with binary catalytic system consisting of benzyl alcohol(BnOH)and organic base(7-methyl-1,5,7-triazabicyclo[4.4.0]dec-5-ene(MTBD))as catalyst,followed by the deprotection for the substitutes on the N atoms groups of the resultant copolymers using K2S2O8/Na2HPO4 system.A detailed study on the debenzylation reaction was carried out.It was found that the K_(2)S_(2)O_(8)/Na_(2)HPO_(4)system can effectively realize the debenzylation reaction involving the copolymer from 2,4-dimethoxy-N-benzylaziridine.The nine kinds of PEAs with different structures were synthesized from two types of monomers.The metal-free strategy,give these PEAs the potential to be utilized as hydrogels,tissue engineering,elastomers and smart materials as well as high-performance engineering plastics.Studies focused on further expanding the monomer scope and controlling the stereochemistry are currently in progress.

关 键 词：聚酯酰胺 脱苄基化反应 无金属催化 交替共聚 

分 类 号：TQ317[化学工程—高聚物工业]