双金属离子交联剂对海藻酸盐凝胶性能的影响  

Effect of bimetallic ion crosslinkers on properties of alginate gel

作　　者：高娟娟 王瑞杰 万凯凯 王恩民 贺志 潘君学 温惠云[1] 黄赛朋[1] 薛伟明[1] GAO Juan-juan;WANG Rui-jie;WAN Kai-kai;WANG En-min;HE Zhi;PAN Jun-xue;WEN Hui-yun;HUANG Sai-peng;XUE Wei-ming(School of Chemical Engineering,Northwest University,Xi′an 710069,Shaanxi Province,China)

机构地区：[1]西北大学化工学院,陕西西安710069

出　　处：《化学工程》2021年第7期1-5,11,共6页Chemical Engineering(China)

基　　金：陕西省自然科学基础研究计划项目(2018JM2037)。

摘　　要：利用Ca^(2+),Ba^(2+),Zn^(2+)与海藻酸钠通过不同配位交联机制形成(Na-Alg)凝胶的特性,两两配伍构建双金属离子交联剂,协同调控Ba-Zn-Alg,Ca-Ba-Alg,Ca-Zn-Alg凝胶微球的结构与性能。采用倒置显微镜、扫描电子显微镜、X射线光电子能谱仪、质构仪等表征微球形貌、结构和力学强度,以牛血清白蛋白(BSA)、罗丹明B(RB)为模式分子评价双金属交联剂对微球负载药物和传质性能的影响。结果表明:Ba^(2+),Zn^(2+)在Alg凝胶中的结合量显著高于Ca^(2+),使Ba-Zn-Alg微球具有致密凝胶结构和较高机械强度;3种微球对BSA的吸附行为属于扩散控制为主的物理吸附,而负载RB微球具有pH值响应释放和扩散传质特征。因此,此研究提供了一种构建微尺度水凝胶药物载体的有效方案。The characteristics of sodium alginate(Na-Alg)gel made by Ca^(2+),Ba^(2+)and Zn^(2+)through different coordination crosslinking mechanisms with sodium alginate were used to construct bimetallic ion crosslinkers by pairing with each other to synergically regulate the structure and properties of Ba-Zn-Alg,Ca-Ba-Alg and Ca-Zn-Alg gel microspheres.The structure of the microspheres was studied by inverted microscope,scanning electron microscope,X-ray photoelectron spectroscopy.Bovine serum albumin(BSA)and Rhodamine B(RB)were used as model molecules to evaluate the effects of bimetallic ion crosslinkerss on drug loading and mass transfer performance of microspheres.The results show that the binding amount of Ba^(2+)and Zn^(2+)in alginate gel is significantly higher than that of Ca^(2+),which makes the Ba-Zn-Alg microspheres have dense gel structure and high mechanical properties.The adsorption behavior of the three microspheres on BSA belongs to diffusion controlled physical adsorption,while the Rhodamine B microspheres have pH response release and diffusion mass transfer characteristics.Therefore,this study provides an effective scheme to construct microscale hydrogel carrier.

关 键 词：海藻酸盐 双金属离子 交联剂 微球 凝胶结构 

分 类 号：TQ021.4[化学工程] O636.1[理学—高分子化学]