石家庄市2019年自然人群8种重点传染病抗体水平调查  

Levels of antibodies against eight major infectious diseases among natural population in Shijiazhuang City,2019

作　　者：刘立[1] 张世勇[1] 张双宅[1] 史艳[1] 刘维华[1] 陈剑珂 LIU Li;ZHANG Shi-yong;ZHANG Shuang-zhai;SHI Yan;LIU Wei-hua;CHEN Jian-ke(Shijiazhuang Municipal Center for Disease Control and Prevention,Shijiazhuang,Hebei 050011,China)

机构地区：[1]石家庄市疾病预防控制中心,河北石家庄050011

出　　处：《实用预防医学》2021年第10期1213-1216,共4页Practical Preventive Medicine

摘　　要：目的了解石家庄市自然人群重点传染病抗体水平和免疫状况,为控制相应疾病、改善免疫策略提供科学依据。方法按整群分层随机抽样原则抽取石家庄市2019年22个县区全人群血清标本共1160份,用酶联免疫吸附试验定量检测麻疹、百日咳、流行性腮腺炎、水痘、白喉、乙脑、流脑、手足口病EV71型的IgG抗体水平。结果石家庄市2019年自然人群麻疹抗体阳性率92.07%,抗体几何平均浓度(geometric mean concentration,GMC)为5204.50 mIU/ml;腮腺炎抗体阳性率84.22%,GMC为772 U/ml;水痘抗体阳性率79.48%,GMC为2059 mIU/ml;白喉抗体阳性率33.02%,GMC为0.35 IU/ml;百日咳抗体阳性率23.88%,GMC为35 IU/ml;EV71、乙脑和流脑抗体阳性率分别为49.22%、18.71%和18.36%。人群百日咳、腮腺炎、水痘的抗体阳性率随着年龄升高而逐渐升高。人群白喉、流脑、乙脑、EV71的抗体阳性率随着年龄升高而逐渐降低。麻疹的抗体水平在1~岁组较高,随着年龄增加逐渐降低至20~组达到最低,之后随着年龄增长缓慢上升。8种重点传染病人群抗体阳性率均无性别差异。22个县区8种重点传染病抗体阳性率差异均有统计学意义,麻疹和腮腺炎抗体阳性率分别为71.70%~100.00%、48.00%~100.00%,差异均有统计学意义(χ^(2)=75.361,P<0.01;χ^(2)=118.569,P<0.01);水痘抗体阳性率为64.06%~92.98%,差异有统计学意义(χ^(2)=69.691,P<0.01);白喉抗体阳性率为0.00~52.46%之间,差异有统计学意义(χ^(2)=206.012,P<0.01);EV71抗体阳性率为27.54%~70.00%,差异有统计学意义(χ^(2)=45.122,P=0.002);流脑、乙脑、百日咳抗体阳性率都低于40%,差异有统计学意义(χ^(2)=78.176,P<0.01;χ^(2)=81.920,P<0.01;χ^(2)=122.908,P<0.01)。接种百日咳、腮腺炎和水痘疫苗人群的抗体阳性率低于未接种疫苗人群的抗体阳性率(百日咳χ^(2)=11.947,P=0.001;腮腺炎χ^(2)=9.354,P=0.002;水痘χ^(2)=61.687,P=0.000)。接种乙脑、流脑和白喉疫苗人群�Objective To analyze the levels of antibodies against eight major infectious diseases and the related immune status among natural population in Shijiazhuang City,and to provide a scientific basis for controlling the relevant diseases and improving the immunization strategy.Methods Twenty-two counties in Shijiazhuang City in 2019 were selected by a stratified random sampling,and a total of 1,160 serum samples from whole population were collected.Enzyme-linked immune-sorbent assay was employed to detect the immunoglobulin G(IgG)antibody levels of measles,pertussis,mumps,chickenpox,diphtheria,epidemic encephalitis B,meningococcal meningitis,and hand,foot and mouth disease(enterovirus 71(EV71)infection).Results The positive rate of IgG antibody against measles among natural population in Shijiazhuang City in 2019 was 92.07%,with geometric mean concentration(GMC)being 5,204.50 mI U/ml.The positive rate of IgG antibody against mumps was 84.22%,with GMC of772.00 U/ml.The positive rate of IgG antibody against chickenpox was 79.48%,with GMC being 2,059 mI U/ml.The positive rate of IgG antibody against diphtheria was 33.02%,with GMC of 0.35 IU/ml.The positive rate of IgG antibody against pertussis was23.88%,with GMC of 35 IU/ml.The positive rates of IgG antibodies against EV71 infection,epidemic encephalitis B,and meningococcal meningitis were 49.22%,18.71%and 18.36%,respectively.The positive rates of IgG antibodies against pertussis,mumps and chickenpox increased gradually with age,while the positive rates of IgG antibodies against diphtheria,meningococcal meningitis,epidemic encephalitis B,and EV71 infection decreased with increasing age.Measles IgG antibody level was higher in the age group of 1-year,and gradually decreased to the lowest in the age group of 20-years,then increased slowly with age growth.No gender difference was found in the positive rates of IgG antibodies against the eight major infectious diseases among natural population.There were statistically significant differences in the positive rates of IgG an

关 键 词：自然人群 重点传染病 抗体 

分 类 号：R446.62[医药卫生—诊断学]