壮药酊联合手指点穴对高血压脑出血术后神经功能和炎症因子的影响  

Effects of Zhuang Yao Ding Combined with Finger Manipulation in Acupoints on Neurological Function and Inflammatory Factors After Surgery of Hypertensive Cerebral Hemorrhage

作　　者：朱雷 李江 安彩梅 陶文姣 ZHU Lei;LI Jiang;AN Caimei;TAO Wenjiao(Dept.of Encephalopathy,Nanning Wuming District Traditional Chinese Medicine Hospital,Guangxi Nanning 530199,China;Dept.of Surgery,Nanning Wuming District Traditional Chinese Medicine Hospital,Guangxi Nanning 530199,China)

机构地区：[1]南宁市武鸣区中医医院脑病科,广西南宁530199 [2]南宁市武鸣区中医医院外科,广西南宁530199

出　　处：《中国医院用药评价与分析》2021年第9期1073-1076,1080,共5页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：南宁市武鸣区科学研究与技术开发计划项目(No.20190306)。

摘　　要：目的:探讨壮药酊联合手指点穴对高血压脑出血术后神经功能和炎症因子的影响。方法:纳入2017年3月至2020年3月于南宁市武鸣区中医医院住院治疗的高血压脑出血术后患者100例作为研究对象,根据随机数字表法分为观察组和对照组,每组50例。对照组患者采用常规康复治疗,观察组患者在常规康复的基础上采用壮药酊联合手指点穴治疗,均治疗6周。观察两组患者的临床疗效,治疗1个月、3个月后的美国国立卫生院卒中神经功能缺损评分量表(national institutes of health stroke scale,NIHSS)评分、肢体运动功能量表(Fugl-Meyer assessment,FMA)评分,血清白细胞介素1β(IL-1β)、γ干扰素(IFN-γ)和白细胞介素10(IL-10)水平;治疗3个月后的格拉斯哥结局量表(Glasgow outcome scale,GOS)评分。结果:观察组患者的总有效率为90.00%(45/50),明显高于对照组的74.00%(37/50),差异有统计学意义(P <0.05)。与对照组相比,观察组患者治疗1个月、3个月后的NIHSS评分降低更明显,FMA评分升高更明显,差异均有统计学意义(P<0.05)。观察组患者治疗3个月后的GOS评分明显高于对照组,差异有统计学意义(P<0.05)。与对照组相比,观察组患者治疗1个月、3个月后的IL-1β、IFN-γ和IL-10水平降低更明显,差异均有统计学意义(P<0.05)。结论:壮药酊联合手指点穴可以改善高血压脑出血术后患者的神经功能,降低炎症因子水平,可进一步开展大样本、多中心临床研究进行验证。OBJECTIVE: To probe into the effects of Zhuang Yao Ding combined with finger manipulation in acupoints on neurological function and inflammatory factors after surgery of hypertensive cerebral hemorrhage.METHODS: Totally 100 inpatients with hypertensive cerebral hemorrhage admitted into Nanning Wuming District Traditional Chinese Medicine Hospital from Mar. 2017 to Mar. 2020 were extracted to be divided into the observation group and the control group via the random number table,with 50 cases in each group. The control group was treated with conventional rehabilitation,while the observation group received Zhuang Yao Ding combined with finger manipulation in acupoints on the basis of conventional rehabilitation,both were treated for 6 weeks. The clinical efficacy,the national institutes of health stroke scale( NIHSS) score,the Fugl-Meyer assessment( FMA) score,serum interleukin 1β( IL-1β),interferon gamma( IFN-γ) and interleukin 10( IL-10) levels after treatment of 1 and 3 months,Glasgow outcome scale( GOS) score after treatment of 3 months in two groups were observed. RESULTS:The total effective rate of the observation group was 90. 00%( 45/50),significantly higher than that of the control group 74. 00%( 37/50),the difference was statistically significant( P < 0. 05). Compared with the control group,NIHSS score decreased more significantly and FMA score increased more significantly in the observation group after treatment of 1 and 3 months,with statistically significant difference( P < 0. 05). GOS score of the observation group was significantly higher than that in the control group after treatment of 3 months,the difference was statistically significant( P < 0. 05). Compared with the control group,the levels of IL-1β,IFN-γ and IL-10 in the observation group decreased more significantly after treatment of 1 and 3 months,with statistically significant difference( P <0. 05). CONCLUSIONS: Zhuang Yao Ding combined with finger manipulation in acupoints on can improve the neurological function of patients after sur

关 键 词：高血压脑出血 壮药酊 点穴 

分 类 号：R944.6[医药卫生—药剂学]