针刺防治化疗引起急性和延迟性呕吐的Meta分析  

Meta-analysis of Acupuncture Prevention and Treatment of Acute and Delayed Vomiting Caused by Chemotherapy

作　　者：邹吉轩 孙妍 宋英 李雨蒙 刘为易 胡晓梅[2] ZOU Jixuan;SUN Yan;SONG Ying;LI Yumeng;LIU Weiyi;HU Xiaomei(Graduate School,Beijing University of Chinese Medicine,Beijing 100029,China;Department of Hematology,Xi Yuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China)

机构地区：[1]北京中医药大学研究生院,北京100029 [2]中国中医科学院西苑医院血液科,北京100091

出　　处：《世界中医药》2021年第18期2735-2741,共7页World Chinese Medicine

基　　金：国家自然科学基金项目(81673821)——基于基因测序、病证结合的骨髓增生异常综合征患者对复方青黄散治疗反应的预测指标研究;中央级公益性科研院所基本科研业务费专项(ZZ10-016)——骨髓增生综合征的中医药防治研究。

摘　　要：目的:评价针刺防治治疗化疗引起急性和延迟性呕吐的临床效果。方法:检索中国期刊全文数据库、中国学术期刊数据库、中文科技期刊数据库、中国生物医学数据库,收集有关针刺治疗化疗引起急性和延迟性呕吐的中文随机对照试验(RCT)和临床对照试验(CCT),检索时间为建库至2020年1月31日,使用软件Rev Man 5.3进行Meta分析。结果:最终纳入20个RCT和CCT,共纳入1458例。与对照组比较,针刺能显著降低化疗引起急性呕吐(RR=0.71,95%CI为0.60~0.84,Z=3.93,P<0.0001)、24~48 h延迟性呕吐(RR=0.61,95%CI为0.52~0.72,Z=5.96,P<0.00001)、48~72 h延迟性呕吐(RR=0.80,95%CI为0.71~0.89,Z=3.86,P=0.0001)的发生率。与对照组比较,针刺对化疗引起的急性呕吐(RR=1.07,95%CI为1.03~1.11,Z=3.40,P=0.0007),24~48 h延迟性呕吐(RR=1.12,95%CI为1.07~1.18,Z=4.97,P<0.00001)以及48~72 h延迟性呕吐(RR=1.09,95%CI为1.03~1.14,Z=3.30,P=0.001)的疗效比较显著。结论:针刺可降低化疗引起急性呕吐和延迟性呕吐的发生率,对化疗引起的急性和延迟性呕吐有较好的治疗作用。Objective:To evaluate the efficacy of acupuncture for the prevention of acute and delayed chemotherapy-induced vomiting.Methods:Database search included the Chinese Journal Full-text Database(CJFD),China Academic Journal Database(CSPD),Chinese Sci-tech Journal Database(CCD),China Biomedical Database(CBM),and Chinese information about acupuncture treatment of acute and delayed vomiting caused by chemotherapy were collected.Randomized Controlled Trials(RCT)and Clinical Controlled Trials(CCT)were collected,and the search time was from the establishment of the database to January 31,2020,and the software Rev Man 5.3 was used for meta-analysis.Results:Finally,20 RCTs and CCTs were included,and a total of 1458 cases were included.The results showed that compared with the control group,acupuncture can significantly reduce chemotherapy-induced acute vomiting(RR=0.71,95%CI 0.60 to 0.84,Z=3.93,P<0.0001)and 24 to 28 h delayed vomiting(RR=0.61,95%CI 0.52 to 0.72,Z=5.96,P<0.00001),48 to 72 h delayed vomiting(RR=0.80,95%CI 0.71 to 0.89,Z=3.86,P=0.0001)incidence rate.Compared with the control group,acupuncture has an effect on acute vomiting caused by chemotherapy(RR=1.07,95%CI 1.03 to 1.11,Z=3.40,P=0.0007)and 24 to 48 h delayed vomiting(RR=1.12,95%CI was 1.07 to 1.18,Z=4.97,P<0.00001)and 48 to 72 h delayed vomiting(RR=1.09,95%CI was 1.03 to 1.14,Z=3.30,P=0.001).The curative effect was more significant.Conclusion:Acupuncture could reduce the incidence of chemotherapy-induced acute vomiting and delayed vomiting,and had a good effect on the treatment of chemotherapy-induced delayed vomiting.

关 键 词：针刺 化疗 急性 延迟性 呕吐 疗效 META分析 

分 类 号：R245[医药卫生—针灸推拿学]