脑损伤通过调控微小RNA对骨折愈合影响的研究进展  

Research progress on the effect of brain injury on fracture healing by regulating microRNAs

作　　者：徐英杰 卜宪敏[2] 池玉磊 田荣华 王海滨[3] 吴彬[3] Xu Yingjie;Bu Xianmin;Chi Yulei;Tian Ronghua;Wang Haibin;Wu Bin(Clinical Institute,Jining Medical University,Jining 272067,China;Jining No.1 People′s Hospital,Jining 272011,China;Department of Orthopedics,Affiliated Hospital of Jining Medical University,Jining 272029,China)

机构地区：[1]济宁医学院临床医学院,272067 [2]济宁市第一人民医院病理科,272011 [3]济宁医学院附属医院骨科,272029

出　　处：《中华实验外科杂志》2021年第10期2093-2096,共4页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金(81572205);山东省自然科学基金青年基金(ZR2014CQ042);济宁医学院教师扶持基金(JYFC2018FKJ048);济宁医学院贺林院士基金(JYHL2018FMS13);济宁市科技局医养健康基金(2018SMNS002)。

摘　　要：骨折合并创伤性脑损伤(TBI)是常见的创伤疾病,微小RNA(miRNA,miR)在创伤性脑损伤对骨折愈合影响过程中发挥重要的作用。大量研究表明,脑损伤会加速骨折愈合,并且miRNA在这过程中扮演着重要角色。miRNA通过各种机制来影响成骨细胞和破骨细胞的生成,来调节骨折的愈合。目前,以miRNA作为靶向药物用来骨折愈合的治疗正处于发展的初级阶段,是一种很有前景的骨折愈合治疗方法。Fracture combined with traumatic brain injury(TBI)is a common traumatic disease.MicroRNAs(miRNA,miR)play an important role in the influence of traumatic brain injury on fracture healing.Numerous studies have shown that brain injury accelerates fracture healing,and miRNA play an important role in this process.miRNA regulate fracture healing by influencing the generation of osteoblasts and osteoclasts through various mechanisms.Currently,the treatment using miRNA as targeted drugs for fracture healing is in the primary stage of development,and it is a promising fracture healing treatment method.

关 键 词：创伤性脑损伤 骨折愈合 微小RNA 靶向药物 

分 类 号：R683[医药卫生—骨科学] R651.15[医药卫生—外科学]