Current Status and Challenge of Pseudorabies Virus Infection in China  

作　　者：Lei Tan Jun Yao Yadi Yang Wei Luo Xiaomin Yuan Lingchen Yang Aibing Wang 

机构地区：[1]Laboratory of Animal Disease Prevention and Control and Animal Model,Hunan Provincial Key Laboratory of Protein Engineering in Animal Vaccines,College of Veterinary Medicine,Hunan Agricultural University(HUNAU),Changsha,410128,China [2]PCB Biotechnology LLC,Rockville,MD,20852,USA [3]Yunnan Tropical and Subtropical Animal Virus Diseases Laboratory,Yunnan Animal Science and Veterinary Institute,Kunming,650224,China [4]Department of Animal Science and Technology,Huaihua Vocational and Technical College,Huaihua,418000,China

出　　处：《Virologica Sinica》2021年第4期588-607,共20页中国病毒学（英文版）

基　　金：This work was supported by the General Program of National Natural Science Foundation of China(Grants No.31571432/31802252);the Hunan Provincial Natural Science Foundation of China(Grant No.2015JC3097/2020JJ4041);the Postgraduate Scientific Research Innovation Project of Hunan Province(CX20200659).

摘　　要：Pseudorabies(PR),also called Aujeszky's disease,is a highly infectious disease caused by pseudorabies virus(PRV).Without specific host tropism,PRV can infect a wide variety of mammals,including pig,sheep,cattle,etc.,thereby causing severe clinical symptoms and acute death.PRV was firstly reported in China in 1950s,while outbreaks of emerging PRV variants have been documented in partial regions since 2011,leading to significant economic losses in swine industry.Although scientists have been devoting to the design of diagnostic approaches and the development of vaccines during the past years,PR remains a vital infectious disease widely prevalent in Chinese pig industry.Especially,its potential threat to human health has also attracted the worldwide attention.In this review,we will provide a summary of current understanding of PRV in China,mainly focusing on PRV history,the existing diagnosis methods,PRV prevalence in pig population and other susceptible mammals,molecular characteristics,and the available vaccines against its infection.Additionally,promising agents including traditional Chinese herbal medicines and novel inhibitors that may be employed to treat this viral infection,are also discussed.

关 键 词：Pseudorabies virus(PRV) Diagnosis methods PREVALENCE Multiple-species infection Prevention and control measures 

分 类 号：S855.3[农业科学—临床兽医学]