拉莫三嗪所致药疹的研究进展  

Lamotrigine-induced drug eruptions

作　　者：肖扬 张晓光[1] Xiao Yang;Zhang Xiaoguang(Department of Dermatology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China)

机构地区：[1]河北医科大学第二医院皮肤科,石家庄050000

出　　处：《中华皮肤科杂志》2021年第10期927-930,共4页Chinese Journal of Dermatology

基　　金：河北省医学科学研究重点课题计划项目(20160131)。

摘　　要：拉莫三嗪(LTG)是一种新型治疗癫痫、双相情感障碍及神经痛的药物,常见的不良反应是药疹,如固定性药疹、急性泛发性发疹性脓疱病、中毒性表皮松解坏死型药疹、药物超敏反应综合征等。LTG引起药疹包括免疫和非免疫机制。HLA等位基因与LTG引起的药疹相关,有种族差异,且与药疹类型有关。本文总结LTG引起的药疹病因、发病机制、临床特点等,以期指导临床用药。Lamotrigine is a new type of drug for the treatment of epilepsy,bipolar affective disorder and neuralgia.Drug eruptions are the common adverse reaction to lamotrigine,such as fixed drug eruption,acute generalized exanthematous pustulosis,toxic epidermal necrolysis,drug-induced hypersensitivity syndrome,etc.The pathogenesis of lamotrigine-induced drug eruptions includes immune and non-immune mechanisms.HLA alleles are related to drug eruptions caused by lamotrigine,and their relationship varies with the race of populations and type of drug eruptions.This review summarizes the etiology,pathogenesis and clinical characteristics of drug eruptions caused by lamotrigine,aiming to guide clinical treatment.

关 键 词：药疹 HLA抗原 拉莫三嗪 

分 类 号：R758.25[医药卫生—皮肤病学与性病学]