血清FSTL1、MIP-2和NT-proBNP在重症肺炎合并心力衰竭患者中表达及与预后关系研究  

Serum FSTL1,MIP-2 and NT-proBNP expression in patients with severe pneumonia complicated with heart failure and their relationship with prognosis.

作　　者：李俊梅 李荣荣 陈晓娟 胡晓雷 米丹丽 李建英 LI Jun-mei;LI Rong-rong;CHEN Xiao-juan(Department of Critical Care Medicine,Zhangjiakou First Hospital,Zhangjiakou Heibei 075000,China.)

机构地区：[1]张家口市第一医院重症医学科,河北张家口075000

出　　处：《临床和实验医学杂志》2021年第17期1828-1831,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省卫生健康委员会项目(编号:20200524);张家口市科学技术局项目(编号:2021109D)。

摘　　要：目的探讨血清卵泡抑素样蛋白1(FSTL1)、巨噬细胞炎性蛋白-2(MIP-2)和氨基末端脑钠肽前体(NT-proBNP)在重症肺炎合并心力衰竭患者中表达及与预后关系。方法回顾性选择于2019年1月至2021年1月张家口市第一医院收治的重症肺炎合并心力衰竭患者98例作为观察组;选择同期重症肺炎患者85例作为对照组;另选择同期健康体检者80例作为正常组。采用酶联免疫吸附试验测定血清FSTL1、MIP-2和NT-proBNP水平。比较各组血清FSTL1、MIP-2和NT-proBNP水平变化;不同预后血清FSTL1、MIP-2和NT-proBNP水平变化;经受试者工作特征(ROC)曲线分析FSTL1、MIP-2和NT-proBNP水平对预后不良预测价值;采用Pearson分析FSTL1、MIP-2和NT-proBNP水平与预后不良相关性。结果观察组血清FSTL1、MIP-2和NT-proBNP分别为(12.41±2.65)ng/mL、(73.24±8.98)pg/mL、(675.28±54.25)pg/mL,均高于对照组[(8.25±1.72)ng/mL、(47.92±7.65)pg/mL和(185.26±27.38)pg/mL]及正常组[(3.37±0.68)ng/mL、(14.15±3.24)pg/mL和(30.18±5.45)pg/mL],差异均有统计学意义(P<0.05);且对照组血清FSTL1、MIP-2和NT-proBNP水平高于正常组,差异均有统计学意义(P<0.05)。预后不良组血清FSTL1、MIP-2和NT-proBNP分别为(16.98±3.24)ng/mL、(86.98±7.65)pg/mL、(786.92±76.52)pg/mL,均高于预后良好组[(4.86±1.18)ng/mL、(25.32±3.68)pg/mL和(227.12±32.27)pg/mL],差异均有统计学意义(P<0.05)。经ROC曲线分析,FSTL1对预后不良诊断灵敏度为80.00%,特异度为50.00%;MIP-2对预后不良诊断灵敏度为66.67%,特异度为44.44%;NT-proBNP对预后不良诊断灵敏度为92.86%,特异度为77.78%。经Pearson相关性分析,血清FSTL1、MIP-2和NT-proBNP与预后不良呈线性正相关(P<0.05)。结论血清FSTL1、MIP-2和NT-proBNP水平在重症肺炎合并心力衰竭患者明显升高,且与预后密切相关。Objective To investigate the expression of serum follostatin-like protein 1(FSTL1),macrophage inflammatory protein-2(MIP-2)and N-terminal pro-brain natriuretic peptide(NT-proBNP)in patients with severe pneumonia and heart failure And the relationship with prognosis.Methods The 98 patients with severe pneumonia combined with heart failure in Zhangjiakou First Hospital from January 2019 to January 2021 were retrospectively selected as the observation group;85 patients with severe pneumonia during the same period were selected as the control group;another 80 patients with healthy physical examination during the same period were selected As a normal group.Enzyme-linked immunosorbent assay was used to determine serum FSTL1,MIP-2 and NT-proBNP levels.The changes of serum FSTL1,MIP-2 and NT-proBNP levels in each group were compared;the changes of serum FSTL1,MIP-2 and NT-proBNP levels in different prognosis;the value of FSTL1,MIP-2 and NT-proBNP levels by ROC curve in predicting poor prognosis was analyzed;Pearson was used to analyze the correlation between FSTL1,MIP-2 and NT-proBNP levels and poor prognosis.Results The levels of serum FSTL1,MIP-2 and NT-proBNP in the observation group were(12.41±2.65)ng/mL,(73.24±8.98)pg/mL,and(675.28±54.25)pg/mL,which were higher than those in the control group[(8.25±1.72)ng/mL,(47.92±7.65)pg/mL and(185.26±27.38)pg/mL]and the normal group[(3.37±0.68)ng/mL,(14.15±3.24)pg/mL and(30.18±5.45)pg/mL],the differences were statistically significant(P<0.05);and the levels of serum FSTL1,MIP-2 and NT-proBNP in the control group were higher than those in normal group,the differences were statistically significant(P<0.05).the levels of serum FSTL1,MIP-2 and NT-proBNP in the poor prognosis group were(16.98±3.24)ng/mL,(86.98±7.65)pg/mL,and(786.92±76.52)pg/mL,respectively,which were higher than those in the good prognosis group[(4.86±1.18)ng/mL,(25.32±3.68)pg/mL and(227.12±32.27)pg/mL],the differences were statistically significant(P<0.05).According to ROC curve analysis,the sensitivi

关 键 词：重症肺炎 心力衰竭 卵泡抑素样蛋白1 巨噬细胞炎性蛋白-2 氨基末端脑钠肽前体 预后 

分 类 号：R541.6[医药卫生—心血管疾病] R563.1[医药卫生—内科学]