焦虑抑郁障碍老年冠心病患者血清CA153、TNF-α表达水平的影响及临床意义  

Effect and clinical significance of serum CA153 and TNF-αexpression in elderly patients with coronary heart disease complicated with anxiety and depression.

作　　者：蒋守涛 吴永刚 王锐 叶少强 聂鹏飞 李幸洲 吴国宝 JIANG Shou-tao;WU Yong-gang;WANG Rui(Department of Cardiovascular Medicine,Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine,Guangzhou Guangdong 510800,China.)

机构地区：[1]广州市中西医结合医院心血管内科,广东广州510800

出　　处：《临床和实验医学杂志》2021年第17期1831-1834,共4页Journal of Clinical and Experimental Medicine

基　　金：广东省中医药局科研项目(编号:20181216)。

摘　　要：目的研究焦虑抑郁障碍对老年冠心病患者血清CA153、肿瘤坏死因子-α(TNF-α)表达水平的影响及临床意义。方法回顾性选取2016年8月至2019年10月广州市中西医结合医院收治的180例冠心病患者,按照汉密尔顿焦虑量表(HAMA)及汉密尔顿抑郁量表(HAMD)评分分为焦虑抑郁组(n=96)与非焦虑抑郁组(n=84)。另选择同期体检健康者作为对照组(n=85)。冠心病患者根据具体病情给予经皮冠状动脉介入治疗或其他治疗方案,于术前、术后1个月检测焦虑抑郁组、非焦虑抑郁组CA153、TNF-α表达水平及HAMA、HAMD评分。对照组于体检当日检测以上指标。采用Pearson相关系数分析法分析CA153、TNF-α表达水平与HAMA、HAMD评分相关性。结果术前,焦虑抑郁组CA153、TNF-α表达水平、HAMA及HAMD评分均高于非焦虑抑郁组及对照组(P<0.05);非焦虑抑郁组术前CA153、TNF-α表达水平高于对照组,差异均有统计学意义(P<0.05);术后1个月,焦虑抑郁组CA153、TNF-α表达水平、HAMA及HAMD评分均低于本组术前(P<0.05),但仍高于术后非焦虑抑郁组,差异均有统计学意义(P<0.05);非焦虑抑郁组术后CA153、HAMA及HAMD评分与本组术前比较,差异无统计学意义(P>0.05)。血清CA153与TNF-α在冠心病患者中与HAMA、HAMD评分均呈正相关(P<0.05)。结论冠心病患者中血清CA153与TNF-α高表达,与患者焦虑抑郁程度呈正比,高血清CA153与TNF-α表达水平是冠心病患者焦虑抑郁障碍发生的原因之一。Objective To investigate the effect and clinical significance of serum CA153 and tumor necrosis factor-α(TNF-α)expression in elderly patients with coronary heart disease complicated with anxiety and depression.Methods One hundred and eighty cases of elderly patients with coronary heart disease admitted to Guangzhou Hospital of Integrated Traditional Chinese and Western Medicine from August 2016 to October 2019 were retrospectively enrolled,and divided into two groups according to the scores of Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD),anxiety-depression group(n=96)and non anxiety-depression group(n=84),meanwhile,another 85 healthy individuals were enrolled as control group.All patients received percutaneous coronary intervention treatment.Serum CA153 and TNF-αlevels,as well as the scores of HAMA and HAMD were detected in all groups.Then the correlation of CA153 and TNF-αlevels with HAMA and HAMD scores was determined by Pearson correlation analysis.Results The levels of serum CA153 and TNF-α,as well as the scores of HAMA and HAMD in anxiety-depression group before operation were higher than those in non anxiety-depression group and control group(P<0.05).The level of serum CA153,TNF-αin non anxiety-depression group was higher than those in control group before operation(P<0.05).One month after operation,serum CA153 and TNF-αlevels,as well as the scores of HAMA and HAMD were decreased in anxiety-depression group(P<0.05),while were still higher than those in non anxiety-depression group(P<0.05).The levels of serum CA153,as well as the scores of HAMA and HAMD in non anxiety-depression group had no significant changes before and One month after operation(P>0.05).Serum CA153 and TNF-αwere positively correlated with HAMA and HAMD scores in patients with coronary heart disease(P<0.05).Conclusion Serum CA153 and TNF-αlevels are elevated in elderly patients with coronary heart disease,which are positively correlated with scores of HAMA and HAMD,so the decrease of serum CA153 and TNF-αexpress

关 键 词：冠心病 焦虑抑郁障碍 糖类抗原153 肿瘤坏死因子-Α 

分 类 号：R541.4[医药卫生—心血管疾病]