妊娠期糖尿病患者血清镁离子、铬离子、血管内皮细胞黏附分子-1及外周血内皮祖细胞检测的临床意义  

Clinical significance of serum magnesium ion,chromium ion,vascular endothelial cell adhesion molecule-1 and peripheral blood endothelial progenitor cells in gestational diabetes mellitus.

作　　者：张艳赏[1] 李丽[1] 刘素新[1] 刘晓丹 王润芳 刘玉华[1] ZHANG Yan-shang;LI Li;LIU Su-xin(Department of Obesterics,People Hospital of Hebei Province,Shijiazhuang Hebei 050051,China.)

机构地区：[1]河北省人民医院产科,河北石家庄050051

出　　处：《临床和实验医学杂志》2021年第17期1869-1872,共4页Journal of Clinical and Experimental Medicine

基　　金：河北省卫生部医药卫生科技项目(编号:20200713)。

摘　　要：目的妊娠期糖尿病(GDM)患者血清镁离子、铬离子、血管内皮细胞黏附分子-1(VCAM-1)及外周血内皮祖细胞(EPCs)检测的临床意义。方法回顾性选取2019年8月至2020年12月河北省人民医院产科收治的168例妊娠期糖尿病患者作为GDM组。同时选取165例正常孕妇作为对照组。抽取静脉血测定血清镁离子、铬、钙、磷离子,VCAM-1及外周EPCs数量,同时测定高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A(APOA)、载脂蛋白B(APOB)等生化指标。受试工作曲线(ROC)分析血清镁离子、铬离子水平、VCAM-1浓度及外周EPCs含量与发生不良妊娠结局的关系。结果观察组患者血清镁及铬分别为(0.52±0.08)nmol/L及(0.20±0.04)μmol/L,均显著低于对照组[(0.88±0.12)nmol/L、(0.38±0.06)μmol/L],差异均有统计学意义(P<0.05)。观察组患者血清TG及VCAM-1水平为(2.21±0.62)mmol/L、(356.33±26.99)mg/dL,显著高于对照组[(1.57±0.48)mmol/L、(295.67±24.56)mg/dL],差异均有统计学意义(P<0.05),而TC、ApoAl、HDL-C、LDL-C及ApoA1水平差异无统计学意义(P>0.05)。观察组患者EPCs百分比数为(0.042±0.011)%,EPCs数量为(37.29±4.76)×10^(6) cell,显著低于对照组,差异有统计学意义(P<0.05)。观察组患者不良妊娠结局发生率为30.95%,显著高于对照组的16.97%,差异有统计学意义(P<0.05)。VCAM-1及外周血内皮祖细胞含量预测发生不良妊娠结局的ROC曲线AUC分别为0.632及0.673,且敏感度和特异性优于血清镁离子和铬离子。结论GDM患者血清镁离子、铬离子水平及外周血内皮祖细胞含量较正常妊娠孕妇显著降低,VCAM-1水平明显上升,且VCAM-1和EPCs含量对评估GDM妊娠结局有一定的指导意义,可辅助诊断、预测不良妊娠结局发生情况。Objective To investigate the clinical significance of serum magnesium ion,chromium ion,vascular endothelial cell adhesion molecule-1 and peripheral blood endothelial progenitor cells in patients with gestational diabetes mellitus.Methods A total of 168 patients with gestational diabetes admitted to obstetrics department were selected as the GDM group from August 2019 to December 2020.At the same time,165 normal pregnant women were selected as control group.The venous blood was obtained,the serum magnesium,chromium,calcium,phosphorus ion,VCAM 1 and peripheral number of EPCs,biochemical method and high density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),apolipoprotein A(APOA),apolipoprotein B(APOB),and other biochemical indicators were determinated.Participants working curve(ROC)was used to analyze the relationship between the serum magnesium ions,chromium ion levels,VCAM 1 concentration and peripheral EPCs content and the adverse pregnancy outcome.Results The levels of serum magnesium and chromium in observation group were(0.52±0.08)nmol/L and(0.20±0.04)μmol/L,respectively,which were significantly lower than those in control group(0.88±0.12)nmol/L,(0.38±0.06)μmol/L,the levels of serum TG and VCAM-1 in the observation group were(2.21±0.62)mmol/L and(356.33±26.99)mg/dL,which were significantly higher than those in the control group[(1.57±0.48)mmol/L and(295.67±24.56)mg/dL],and the differences were statistically significant(P<0.05).While the TC,ApoAl,HDL-C,LDL-C and ApoA1 level difference had no statistical significance(P>0.05).The count of EPCs in observation group was(0.042±0.011)%,and the number of EPCs in observation group was(37.29±4.76)×106 cell,which were significantly lower than those in control group[(0.083±0.012)%,(50.47±5.84)×10^(6) cell],and the differences were statistically significant(P<0.05).The incidence of adverse pregnancy outcome in observation group was 30.95%,which was significantly higher than that 16.97%in control group,the difference was statistic

关 键 词：妊娠期糖尿病 镁离子 铬离子 血管内皮细胞黏附分子-1 外周血内皮祖细胞 

分 类 号：R714.256[医药卫生—妇产科学]