软通道微创穿刺引流术对高血压脑出血患者术后血清sTREM-1和PCT水平的影响  

Effect of soft channel minimally invasive drainage on serum sTREM-1 and PCT levels in patients with hypertensive intracerebral hemorrhage after surgery

作　　者：徐敬斌[1] 常奎[1] 王鑫 XU Jing-bin;CHANG Kui;WANG Xin(Department of Neurosurgery,The Second People's Hospital of Fuyang City,Fuyang Anhui 236000,China.)

机构地区：[1]阜阳市第二人民医院神经外科,安徽阜阳236000

出　　处：《临床和实验医学杂志》2021年第18期1967-1970,共4页Journal of Clinical and Experimental Medicine

基　　金：安徽省中医药传承创新科研项目(编号:2020zcyb20)。

摘　　要：目的探讨软通道微创穿刺引流术对高血压脑出血患者术后血清可溶性髓系细胞触发受体-1(sTREM-1)和降钙素原(PCT)水平的影响。方法前瞻性选取2018年3月到2020年3月在阜阳市第二人民医院诊治的高血压脑出血患者65例,根据随机信封抽签原则把患者分为软通道组33例与硬通道组32例。软通道组给予软通道微创穿刺引流术治疗,硬通道组给予硬通道微创穿刺引流术治疗。观察与记录2组术后28 d格拉斯哥预后评分(GOS),术前与术后28 d的NIHSS评分与Barthel指数评分,记录术后28 d出现的颅内感染与再出血等并发症情况,检测血清sTREM-1、PCT水平。结果软通道组术后28 d的GOS评分好于硬通道组,差异有统计学意义(P<0.05)。术前,2组患者NIHSS评分、Barthel指数评分比较,差异均无统计学意义(P>0.05);术后28 d,软通道组NIHSS评分为(9.43±1.14)分,显著低于硬通道组[(14.56±2.00)分],Barthel指数评分为(69.28±4.11)分,显著高于硬通道组[(51.57±3.78)分],差异均有统计学意义(P<0.05)。软通道组术后28 d的再出血与颅内感染发生率分别为3.0%、3.0%,均低于硬通道组(15.6%和18.6%),差异有统计学意义(P<0.05)。术前,2组患者血清sTREM-1和PCT水平比较,差异均无统计学意义(P>0.05);术后28 d,软通道组血清sTREM-1和PCT水平为(7.18±0.35)ng/L、(3.15±0.21)ng/mL,均显著低于硬通道组[(17.92±2.77)ng/L、(6.28±0.88)ng/mL],差异均有统计学意义(P<0.05)。结论软通道微创穿刺引流术在高血压脑出血患者的应用能抑制术后血清sTREM-1和PCT的表达,减少术后并发症的发生,促进改善患者的预后神经与日常生活能力,从而提高治疗效果。Objective To investigate the effects of minimally invasive soft channel drainage on soluble triggering receptor expressed on myeloid cells-l(sTREM-1)and procalcitonin(PCT)in serum of patients with hypertensive intracerebral hemorrhage after surgery.Methods From March 2018 to March 2020,65 cases of patients with hypertensive cerebral hemorrhage diagnosed and treated in The Second People's Hospital of Fuyang City were prospectively selected.All the cases were divided into soft channel group with 33 cases and hard channel group with 32 cases according to the principle of random envelope drawing.The soft channel group were given the soft channel minimally invasive drainage treatment,and the hard channel group were given the hard channel minimally invasive drainage treatment.Glasgow Outcome Score(GOS)at 28 days after operation in the 2 groups,NIHSS score and Barthel index score before and 28 days after operation were observed and recorded,and complications such as intracranial infection and rebleeding on 28 days after operation were recorded.Serum sTREM-1 and PCT levels were detected.Results The Glasgow Outcome Scale(GOS)of the soft channel group were better than that of the hard channel group at 28 days after operation,the difference was statistically significant(P<0.05).Before operation,the comparison of NIHSS score and Barthel index score between the two groups was not statistically significant(P>0.05);at 28 days after operation,the NIHSS scores of the soft channel group were(9.43±1.14)points,which were significantly lower than those of the hard channel group[(14.56±2.00)points],the Barthel index scores were(69.28±4.11)points,which were significantly higher than those of the hard channel group[(51.57±3.78)points],and the differences were statistically significant(P<0.05).The incidence of rebleeding and intracranial infection at 28 days after operation in the soft channel group were 3.0%and 3.0%,respectively,which were lower than those in the hard channel group(15.6%and 18.6%),and the difference was statisticall

关 键 词：高血压脑出血 软通道 微创穿刺引流术 可溶性髓系细胞触发受体-1 降钙素原 

分 类 号：R651.1[医药卫生—外科学]