连翘养荣汤联合负压引流技术对四期压疮的辅助治疗效果及其对炎性因子的影响  

The Adjuvant Therapeutic Effect of Forsythia Yangrong Decoction Combined with Vacuum Sealing Drainage on Four-stage Pressure Ulcer and Its Influence on Inflammatory Factors

作　　者：李少荣[1] 赵俊卿 刘小娜 张丽荣[1] 耿冰 王军静[1] 彭冀[1] LI Shao-rong;ZHAO Jun-qing;LIU Xiao-na(The Second Department General Surgery,The Second Affiliated Hospital of Xingtai Medical College in Xingtai City of Hebei Province,Xingtai,Hebei(054000),China)

机构地区：[1]河北省邢台市邢台医学高等专科学校第二附属医院,河北邢台054000 [2]河北省邢台市第三医院,河北邢台054099

出　　处：《中国中西医结合外科杂志》2021年第5期743-747,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：邢台市科技计划项目(2019ZC335)。

摘　　要：目的:探讨连翘养荣汤联合负压引流技术(VSD)对四期压疮的辅助治疗效果及对炎性因子的影响。方法:选取2017年1月—2019年1月我院收治的四期压疮患者120例,依据随机数字表分为A组和B组,每组60例,A组给予VSD治疗,B组在此基础上给予连翘养荣汤治疗,比较两组炎性因子[C-反应蛋白(CRP)、白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)]、疼痛[视觉模拟评分(VAS)]、创面愈合情况。结果:A组和B组治疗后CRP、IL-6、TNF-α明显低于治疗前,B组治疗后CRP、IL-6、TNF-α明显低于A组,差异有统计学意义(P<0.05);A组和B组治疗7、14 d后VAS评分明显低于治疗前,B组治疗7、14 d后VAS评分明显低于A组,差异有统计学意义(P<0.05);B组治疗有效率明显高于A组,B组换药次数、创面愈合时间、治疗费用明显低于A组,差异有统计学意义(P<0.05)。结论:连翘养荣汤联合VSD可有效减少四期压疮患者炎性因子及疼痛,有利于提高患者治疗效果,值得临床推广。Objective To discuss the adjuvant therapeutic effect of Forsythia Yangrong decoction combined with vacuum sealing drainage(VSD)on four-stage pressure ulcer and its influence on inflammatory factors.Methods 120 patients with four-stage pressure ulcer from January 2017 to January 2019 were selected,they were divided into group A and group B according to the random number table,which 60 patients in each group.The group A was treated with VSD,the group B was treated with Forsythia Yangrong decoction on the basis.The inflammatory factors[C-reactive protein(CRP),interleukin-6(IL-6),tumor necrosis factor-alpha(TNF-alpha)],pain[visual analogue score(VAS)]and wound healing were compared between the two groups.Results The CRP,IL-6 and TNF-alpha in group A and group B after treatment were significantly lower than those before treatment.The CRP,IL-6 and TNF-alpha in group B after treatment were significantly lower than those in group A,which the differences were statistically significant(P<0.05).The VAS scores in group A and B after treatment 7 and 14 days were significantly lower than those before treatment.The VAS scores in group B after treatment 7 and 14 days were significantly lower than those in group A,which the differences were statistically significant(P<0.05).The effective rate in group B was significantly higher than that in group A.The number of dressing changes,wound healing time and treatment cost in group B were significantly lower than those in group A,which the differences were statistically significant(P<0.05).Conclusion Forsythia Yangrong decoction combined with VSD can effectively reduce the inflammatory factors and pain in patients with stage IV pressure ulcer,which is helpful to improve the therapeutic effect of patients.It's worth for further clinical promotion.

关 键 词：连翘养荣汤 负压引流技术 四期压疮 治疗效果 炎性因子 

分 类 号：R632.1[医药卫生—外科学]