非洲猪瘟病毒与天然免疫系统相互作用研究进展  

Interaction between African swine fever virus and host innate immune system

作　　者：屈海龙 戈胜强[1] 张永强[1] 韩乃君 孙成友[1] 吴晓东[1] 王志亮[1] QU Hailong;GE Shengqiang;ZHANG Yongqiang;HAN Naijun;SUN Chengyou;WU Xiaodong;WANG Zhiliang(China Animal Health and Epidemiology Center,Qingdao,Shandong 266032,China)

机构地区：[1]中国动物卫生与流行病学中心,山东青岛266032

出　　处：《中国兽医学报》2021年第9期1879-1886,共8页Chinese Journal of Veterinary Science

基　　金：“十三五”国家重点研发计划资助项目(2017Y-FD0501801)。

摘　　要：非洲猪瘟病毒(ASFV)可引起家猪和野猪的出血热,在非洲、欧洲和亚洲持续蔓延,对全球养猪业构成严重威胁。因为没有疫苗,难以有效地控制非洲猪瘟流行。ASFV感染能够诱导宿主的天然免疫,也能够通过调节天然免疫效应分子抑制宿主的天然免疫机能。现对ASFV感染与天然免疫反应及其免疫抑制的现象与机理进行综述。African swine fever virus(ASFV)causes haemorrhagic fever in domestic pigs and wild boar.The continuing spread in Africa,Europe and Asia threatens the global pig industry.The lack ofthe vaccine limits disease control.The infection with ASFV can induce host innate immune response,but this virus can suppress the host innate immunity through modulating the expression of effector molecules of the innate immune system.In this review,we highlight the current understanding of host innate immune response and immune suppression during ASFV infection.In addition,we review the mechanisms by which ASFV infection induces innate immunity and its suppression.

关 键 词：非洲猪瘟病毒(ASFV) 天然免疫 干扰素 免疫抑制 凋亡 

分 类 号：S852.65[农业科学—基础兽医学]