中性粒细胞计数和中性粒细胞/淋巴细胞比值在评估2型糖尿病患者合并冠心病中的价值  

Value of neutrophil count and neutrophil to lymphocyte ratio in assessment of type 2 diabetes mellitus patients complicated with coronary heart disease

作　　者：李金燕 杨帆[2] 陆思颜 LI Jin-yan;YANG Fan;LU Si-yan(Graduate School,Guilin Medical University,Guilin 541001,China;Department of Endocrinology,the Affiliated Hospital of Guilin Medical University,Guilin 541001,China)

机构地区：[1]桂林医学院研究生院,广西桂林市541001 [2]桂林医学院附属医院内分泌科,广西桂林市541001

出　　处：《广西医学》2021年第16期1913-1917,共5页Guangxi Medical Journal

基　　金：国家自然科学基金(81460160)。

摘　　要：目的探讨中性粒细胞计数和中性粒细胞/淋巴细胞比值在评估2型糖尿病患者合并冠心病的价值。方法将79例急性胸痛的2型糖尿病患者,根据冠状动脉造影结果分为糖尿病合并冠心病组(A组,至少有1支冠状动脉狭窄程度≥50%)49例和糖尿病合并冠状动脉狭窄组(B组,冠状动脉狭窄程度<50%)30例,另外选取34例正常健康者作为C组。比较3组研究对象的一般资料和血生化指标,并分析2型糖尿病患者合并冠心病的影响因素。采用受试者工作特征曲线分析相关指标评估2型糖尿病患者是否合并冠心病的价值。结果与C组相比,A组、B组年龄、高血压比例、空腹血糖、糖化血红蛋白、尿酸水平均升高,A组男性比例、中性粒细胞计数、三酰甘油水平、LDL-C/HDL-C比值升高,而单核细胞计数、总二氧化碳水平、HDL-C水平、单核细胞/HDL-C比值降低,B组体质指数升高(均P<0.05)。与B组比较,A组男性比例、中性粒细胞计数、中性粒细胞/淋巴细胞比值、LDL-C、LDL-C/HDL-C比值、单核细胞/HDL-C比值、载脂蛋白B水平均升高(均P<0.05)。多因素Logistic回归分析结果显示,中性粒细胞计数是2型糖尿病患者合并冠心病的影响因素(P<0.05)。中性粒细胞计数、中性粒细胞/淋巴细胞比值评估2型糖尿病患者是否合并冠心病的曲线下面积分别为0.857、0.765。结论糖尿病合并冠心病患者中性粒细胞计数和中性粒细胞/淋巴细胞比值升高,其中中性粒细胞计数升高时糖尿病患者合并冠心病的可能性大。中性粒细胞计数和中性粒细胞/淋巴细胞比值在评估2型糖尿病患者是否合并冠心病中具有一定的价值。Objective To explore the value of neutrophil count and neutrophil to lymphocyte ratio in assessing type 2 diabetes mellitus(T2DM)patients complicated with coronary heart disease(CHD).Methods According to the results of coronary angiography,79 T2DM patients with acute chest pain were divided into 49 cases in the diabetes complicated with CHD group(group A,with at least one coronary artery harboring stenosis degree≥50%)and 30 cases in the diabetes complicated with coronary stenosis group(group B,with coronary artery harboring stenosis degree<50%),and another 34 healthy individuals were selected as group C.General data and blood biochemical indicators were compared among the three groups,and the influencing factors of concomitant CHD were analyzed in T2DM patients.Receiver operating characteristic curve was employed to analyze the value of relevant indicators for evaluating the occurrence of concomitant CHD in T2DM patients.Results Compared with group C,group A or B was older,and had higher proportion of hypertension and increased levels of FBG,hemoglobin A1c and uric acid;group A exhibited higher proportion of male cases,higher neutrophil count and TC level,increased LDL-C to HDL-C ratio,decreased monocyte count,total CO 2 level,HDL-C level and monocyte to HDL-C ratio;group B exhibited elevated body mass index(all P<0.05).Compared with group B,group A reported higher proportion of male cases,increased neutrophil count,neutrophil to lymphocyte ratio,LDL-C level,LDL-C to HDL-C ratio,monocyte to HDL-C ratio and lipoprotein B level(all P<0.05).The results of multivariate Logistic regression analysis showed that neutrophil count was the influencing factor of developing concomitant CHD in T2DM patients(P<0.05).The areas under the curve of neutrophil count and neutrophil to lymphocyte ratio for assessing the occurrence of concomitant CHD in T2DM patients were 0.857 and 0.765,respectively.Conclusion Patients with diabetes mellitus complicated with CHD experience elevated neutrophil count and neutrophil to lymphocyte rati

关 键 词：2型糖尿病 冠心病 合并症 中性粒细胞计数 中性粒细胞/淋巴细胞比值 诊断 

分 类 号：R587.1[医药卫生—内分泌]