软骨寡聚基质蛋白水平对膝骨关节炎患者心血管疾病患病风险的预测作用  

Predictive effect of cartilage oligomeric matrix protein level on risk of cardiovascular diseases in patients with knee osteoarthritis

作　　者：孙卫国[1] 杨德文[1] 郝强[1] 孙开旺 尚建军[1] 王顺超[1] SUN Wei-guo;YANG De-wen;HAO Qiang;SUN Kai-wang;SHANG Jian-jun;WANG Shun-chao(Department of Traumatic Hand Surgery,Baotou Fourth Hospital,Baotou 014030,China)

机构地区：[1]内蒙古包头市第四医院创伤手外科,包头市014030

出　　处：《广西医学》2021年第16期1927-1931,共5页Guangxi Medical Journal

基　　金：内蒙古包头市科技计划(2018C2007-4-9)。

摘　　要：目的探讨软骨寡聚基质蛋白(COMP)水平对膝骨关节炎(KOA)患者心血管疾病患病风险的预测价值。方法选取158例KOA患者作为研究组,另选取同期来院体检的100例健康人作为对照组,比较两组研究对象的血清COMP水平。KOA患者出院后随访36个月,其间失访21例,根据随访期间是否发生心血管疾病将137例KOA患者分为患心血管疾病组(n=48)和未患心血管疾病组(n=89),比较患心血管疾病组和未患心血管疾病组入院时的血清COMP水平及相关生化指标,采用Logistic回归模型分析KOA患者发生心血管疾病的影响因素,并采用受试者工作特征(ROC)曲线分析血清COMP水平对KOA患者发生心血管疾病的预测价值。结果研究组的血清COMP水平高于对照组(P<0.05)。患心血管疾病组的体质指数、年龄、COPM水平、C反应蛋白(CRP)水平均高于未患心血管疾病组,HDL-C水平低于未患心血管疾病组(均P<0.05)。Logistic回归分析结果显示,体质指数、年龄、COMP水平、CRP水平、HDL-C水平均是影响KOA患者发生心血管疾病的因素(均P<0.05)。ROC曲线分析结果显示,COMP水平预测KOA患者发生心血管疾病的灵敏度、特异度、准确度、曲线下面积分别为81.02%、76.64%、78.10%、0.881。结论KOA患者血清COMP水平的异常升高,血清COMP升高是KOA患者发生心血管疾病的危险因素,其或可作为预测KOA患者心血管疾病患病风险的预测指标。Objective To explore the predictive value of cartilage oligomeric matrix protein(COMP)level for the risk of cardiovascular diseases in patients with knee osteoarthritis(KOA).Methods A total of 158 patients with KOA were selected as study group,and another 100 concurrent healthy individuals who came to the hospital for physical examination were selected as control group.Serum COMP levels of the subjects were compared between the two groups.KOA patients were followed up for 36 months after discharge and 21 cases were lost to follow-up.According to the incidence of cardiovascular diseases during the follow-up period,137 patients with KOA were divided into cardiovascular diseases group(n=48)and non-cardiovascular diseases group(n=89).Serum COMP level and related biochemical indicators at admission were compared between the cardiovascular diseases group and the non-cardiovascular diseases group.The Logistic regression model was used to analyze the influencing factors of developing cardiovascular diseases in KOA patients,and the receiver operating characteristic(ROC)curve was employed to analyze the predictive value of serum COMP level for the incidence of cardiovascular diseases in KOA patients.Results The study group exhibited a higher serum COMP level than the control group(P<0.05).The cardiovascular diseases group yielded higher body mass index,age,COPM level and C-reactive protein(CRP)level,and lower HDL-C level as compared with the non-cardiovascular diseases group(all P<0.05).The results of Logistic regression analysis showed that body mass index,age,COMP level,CRP level,and HDL-C level were the factors influencing the incidence of cardiovascular diseases in patients with KOA(all P<0.05).The results of ROC curve analysis revealed that the sensitivity,specificity,accuracy,and area under the curve of COMP level for predicting the occurrence of cardiovascular diseases in KOA patients were 81.02%,76.64%,78.10%,and 0.881,respectively.Conclusion KOA patients sustain an abnormal increase in serum COMP level.Serum COMP

关 键 词：膝骨关节炎 心血管疾病 软骨寡聚基质蛋白 合并症 患病风险 预测价值 

分 类 号：R446.1[医药卫生—诊断学]