临床药师干预对痛风患者疾病认知水平、用药情况和治疗效果的影响  

Effect of clinical pharmacist intervention on disease cognition,medication and therapeutic efficacy in gout patients

作　　者：曹利娟[1] 陈仕鹏 谢瑞杰[1] 陆卓莉 李俊明[1] 刘代华[1] CAO Li-juan;CHEN Shi-peng;XIE Rui-jie;LU Zhuo-li;LI Jun-ming;LIU Dai-hua(Department of Pharmacy,Liuzhou People′s Hospital,Liuzhou 545006,China)

机构地区：[1]广西柳州市人民医院药学部,柳州市545006

出　　处：《广西医学》2021年第16期1945-1948,共4页Guangxi Medical Journal

基　　金：广西卫生和计划生育委员会自筹经费科研课题(Z2015116);广西中医药管理局自筹经费科研课题(GZZC2020381)。

摘　　要：目的探讨临床药师干预对痛风患者疾病认知水平、用药情况和治疗效果的影响。方法选取172例痛风患者作为研究对象,住院期间临床药师对其进行痛风相关知识和急性发作期、间歇期用药宣教。比较干预前后患者痛风相关知识认知情况和治疗效果。结果干预后痛风患者的痛风禁忌饮食知晓率、对痛风可导致关节损害、肾脏损害、心血管疾病和糖尿病的危害知晓率、尿酸控制目标知晓率均高于干预前(均P<0.05);干预后痛风患者在急性发作期选择非甾体抗炎药、秋水仙碱治疗的比例均高于治疗前,选择草药、非甾体抗炎药联合糖皮质激素治疗的比例均低于干预前,且痛风患者在间歇期规律服用抑制尿酸合成药物、增加尿酸排泄药的比例高于干预前,间断服用降尿酸药物、不服用降尿酸药物的比例低于干预前(均P<0.05);干预后痛风患者近一年痛风急性发作的次数下降,痛风患者规律复诊的频次增加(均P<0.05)。结论临床药师对痛风患者进行疾病相关知识和用药宣教能有效地提高痛风患者对痛风疾病的认知水平和对痛风的重视程度,有利于提高患者用药依从性,降低痛风急性发作次数。Objective To explore the effect of clinical pharmacist intervention on disease cognition,medication and therapeutic efficacy in gout patients.Methods A total of 172 patients with gout were selected as subjects.Among them,clinical pharmacists carried out inpatient propaganda and education regarding knowledge related to gout and medication in acute attack stage and intermittent stage.The patients′awareness of knowledge related to gout and therapeutic efficacy before and after intervention were compared.Results After intervention,the awareness rate of taboo foods for gout,the awareness rate of knowledge about joint damage,kidney damage,or cardiovascular diseases/diabetes mellitus caused by gout,and the awareness rate of uric acid control targets were higher in gout patients as compared with those before intervention(all P<0.05);after intervention,among gout patients in acute attack period,the proportion of patients with gout who chose nonsteroidal anti-inflammatory drugs or colchicine therapy was higher,and the proportion of patients who were treated with herbal medicine alone,or treated with nonsteroidal anti-inflammatory drugs combined with glucocorticoids,was lower as compared with those before intervention;among gout patients in intermittent stage,the proportion of patients with gout who were administrated drugs regularly to inhibit uric acid synthesis and increase drug consumption for uric acid excretion was higher,and the proportion of patients with or without intermittent administration of uric acid-lowering drugs was lower as compared with those before intervention(all P<0.05);after intervention,patients with gout yielded decreased number of acute attacks of gout in recent year and increased frequency of regular follow-up visits(all P<0.05).Conclusion Propaganda and education regarding knowledge related to gout and medication on gout patients done by clinical pharmacists can effectively improve gout patients′cognition and attitude towards gout disease,contribute to improving patients′medication complia

关 键 词：痛风 临床药师 用药依从性 疾病认知 治疗效果 宣教 

分 类 号：R589.7[医药卫生—内分泌]