Association between serum uric acid level and mortality in China  

作　　者：Dong-Yuan Chang Jin-Wei Wang Min Chen Lu-Xia Zhang Ming-Hui Zhao 

机构地区：[1]Renal Division,Department of Medicine,Peking University First Hospital,Institute of Nephrology,Peking University,Beijing 100034,China [2]Key Laboratory of Renal Disease,National Health Commission of the People’s Republic of China,Beijing 100034,China [3]Key Laboratory of Chronic Kidney Disease Prevention and Treatment,Peking University,Ministry of Education,Beijing 100034,China [4]Research Units of Diagnosis and Treatment of Immune-mediated Kidney Diseases,Chinese Academy of Medical Sciences,Beijing 100034,China

出　　处：《Chinese Medical Journal》2021年第17期2073-2080,共8页中华医学杂志（英文版）

基　　金：This study was supported by grants from the National Natural Science Foundation of China(Nos.91846101,81771938,81900665,82003529,82090021);Beijing Nova Programme Interdisciplinary Cooperation Project(No.Z191100001119008);National Key R&D Program of the Ministry of Science and Technology of China(No.2019YFC2005000);Chinese Scientific and Technical Innovation Project 2030(No.2018AAA0102100);the University of Michigan Health System-Peking University Health Science Center Joint Institute for Translational and Clinical Research(Nos.BMU2018JI012,BMU2019JI005);CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-046);PKU-Baidu Fund(No.2019BD017).

摘　　要：Background:Whether there is an association between serum uric acid(SUA)level and risk of mortality in the general population remains unclear.Based on the China National Survey of Chronic Kidney Disease linked to mortality data,a population-based cohort study was performed to investigate the association between SUA level and all-cause mortality,cardiovascular disease(CVD)mortality,and cancer mortality in China.Methods:The survival status of participants in the cross-sectional survey was identified from January 1,2006 to December 31,2017.Only 33,268 individuals with complete SUA data among the 47,204 participants were included in the analysis.We determined the rates of all-cause mortality,CVD mortality,and cancer mortality.We used Cox proportional hazards regression models to evaluate the effect of the SUA level on mortality.Results:During a total of 297,538.4 person-years of follow-up,1282 deaths occurred.In the Cox proportional hazards regression model,the rate of all-cause mortality,CVD mortality,and cancer mortality had a U-shaped association with SUA levels only in men,whereas no significant associations were detected in women.For all-cause mortality in men,the multivariable-adjusted hazard ratios(HRs)in the first,second,and fourth quartiles compared with the third quartile were 1.31(95%confidence interval[CI]1.04–1.67),1.17(95%CI 0.92–1.47),and 1.55(95%CI 1.24–1.93),respectively.For CVD mortality,the corresponding HRs were 1.47(95%CI 1.00–2.18),1.17(95%CI 0.79–1.75),and 1.67(95%CI 1.16–2.43),respectively.For the cancer mortality rate,only a marginally significant association was detected in the fourth quartile compared with the third quartile with an HR of 1.43(95%CI 0.99–2.08).Conclusions:The association between SUA and mortality differed by sex.We demonstrated a U-shaped association with SUA levels for all-cause and CVD mortalities among men in China.

关 键 词：Cardiovascular diseases Sex characteristics Serum uric acid China Cohort study MORTALITY POPULATION-BASED 

分 类 号：R54[医药卫生—心血管疾病]