抗结核病疫苗佐剂的研究进展  

Advances in adjuvants for tuberculosis vaccines

作　　者：李悄 王伟[1] 李传友[1] Li Qiao;Wang Wei;Li Chuanyou(Department of Bacteriology and Immunology,Beijing Chest Hospital,Capital Medical University,Beijing Key Laboratory of Drug-Resistant Tuberculosis Research,Beijing Tuberculosis and Thoracic Tumor Research Institute,Beijing 101149,China)

机构地区：[1]首都医科大学附属北京胸科医院,北京市结核病胸部肿瘤研究所,耐药结核病研究北京市重点实验室,细菌免疫室,101149

出　　处：《中华微生物学和免疫学杂志》2021年第9期719-725,共7页Chinese Journal of Microbiology and Immunology

基　　金：北京市科技重大专项(D181100000418004)。

摘　　要：佐剂在免疫学中的定义是非特异性免疫增强剂,仅发挥辅助功能,随着各种佐剂的不断出现以及在一些传染病疫苗中的成功应用,其得到了广泛关注与深入研究。本文针对应用于抗结核病疫苗中的佐剂种类、功能及前景做一简要综述,为合理选择佐剂和新型抗结核病疫苗佐剂的研发提供借鉴。The definition of adjuvant in immunology is the non-specific immunopotentiator,which only performs auxiliary functions.With the appearance of various adjuvants and their successful application in some vaccines against infectious disease,they have received extensive attention and been studied in-depth.This review focused on the types,functions and prospects of adjuvants used in tuberculosis vaccines,aiming to provide reference for adjuvant selection and development in future.

关 键 词：佐剂 结核病 结核分枝杆菌 新型疫苗 

分 类 号：R392[医药卫生—免疫学]