乙酰转移酶p300调节细胞因子在急性肺损伤中的研究进展  

Research progress of acetyltransferase p300 regulating cytokines in acute lung injury

作　　者：曾祥丽(综述) 张红(审校) ZENG Xiang-li(reviewing);ZHANG Hong(checking)(Department of Anesthesiology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,Guizhou,China)

机构地区：[1]遵义医科大学附属医院麻醉科,遵义563000

出　　处：《医学研究生学报》2021年第10期1092-1096,共5页Journal of Medical Postgraduates

基　　金：国家自然科学基金(82060083)。

摘　　要：急性肺损伤(ALI)是临床常见且多发的危重症,严重者进展为急性呼吸窘迫综合征。其中,各种病因(如肺炎、创伤、DIC、体外循环等)引起的炎症细胞因子浸润加重了肺损伤进程。乙酰转移酶p300可通过影响炎性细胞因子的表达与释放参与肺损伤。目前针对ALI的防治仍是医学难点,文章就乙酰转移酶p300调节细胞因子与肺损伤的关系进行综述。Acute lung injury(ALI)is one of the most common and frequently critical diseases in clinical practice.In severe cases,ALI can develop into acute respiratory distress syndrome(ARDS).The infiltration of inflammatory cytokines caused by various causes(such as pneumonia,trauma,DIC,cardiopulmonary bypass,etc.)aggravates the process of lung injury.Acetyltransferase p300 may be involved in lung injury by affecting the expression and release of inflammatory cytokines.At present,the prevention and treatment of ALI is still a medical difficulty.In this paper,the relationship between acetyltransferase p300 regulating cytokines and lung injury is reviewed,aiming to provide a new idea for the diagnosis and treatment of ALI.

关 键 词：急性肺损伤 细胞因子 乙酰转移酶p300 

分 类 号：R563[医药卫生—呼吸系统]