肠道微生态与应激反应的关系及其在军事应激中的应用  

Research status of gut microbiota and stress and its application in military stress

作　　者：张娜娜 杨云生[2] 王子恺[2] Zhang Na-Na;Yang Yun-Sheng;Wang Zi-Kai(Medical School of Chinese PLA,Beijing 100853,China;Center for Gastroenterology,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军医学院,北京100853 [2]解放军总医院第一医学中心消化内科医学部,北京100853

出　　处：《解放军医学杂志》2021年第9期871-875,共5页Medical Journal of Chinese People's Liberation Army

基　　金：国防科技委创新培育课题(1716312ZT00204801)。

摘　　要：应激是机体受到内外环境刺激时产生的非特异性反应,参与肠易激综合征、功能性胃肠病、焦虑及抑郁等诸多身心疾病的发生发展,是非战斗减员的主要原因。肠道微生态可通过肠道菌群-肠-脑轴调节机体代谢、免疫及神经系统的发育及功能,影响机体健康及行为,其构成及功能与应激相关疾病的相互作用正逐渐被揭示。肠道微生态的干预及调节或可成为预防及治疗应激相关疾病的新方案,可用于干预军人对军事应激的反应。该文主要从应激反应发生机制、肠道微生态特征及其干预、军事应激相关肠道微生态研究的现状及其应用等方面进行概述。Stress is a non-specific response of the body when suffering from internal or external factors.It is involved in the development and progression of many physical and mental diseases such as irritable bowel syndrome,functional gastrointestinal diseases,anxiety and depression.It is the main cause of non-combat attrition.Gut microbiota can regulate the body’s metabolism,immune and nervous system development and functions through the gut microbiota-gut-brain axis and affect the health and behavior.The interaction between its composition and function and stress-related diseases is gradually being revealed.The intervention and regulation of gut microbiota may become a new solution to prevent and treat stress-related diseases and participate in influencing the reaction of military personnel to military stress.This review focuses on the research progress of stress-related mechanisms,gut microbiota characteristics and related intervention research,the study status of military stress-related and gut microbiota and the prospects of its application.

关 键 词：应激 肠道微生态 肠-脑轴 军事 

分 类 号：R82[医药卫生—临床医学]