基于文献报道中医古方治疗前列腺癌的用药分析  

Analyze the application of ancient prescription in treatment of prostate cancer based on the literature reports

作　　者：吴威 李楠[2] 于长禾[3] 张会永[2,4] WU Wei;LI Nan;YU Chang-he;ZHANG Hui-yong(Zhuhai College of Jilin University,Zhuhai 519041,China;Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications,Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Dongzhimen hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Affiliated Hospital of Liaoning University of traditional Chinese Medicine,Shenyang 110032,China)

机构地区：[1]珠海科技学院,广东珠海519041 [2]辽宁中医药大学中医脏象理论及应用国家教育部重点实验室,辽宁沈阳110847 [3]北京中医药大学东直门医院,北京100700 [4]辽宁中医药大学附属医院,辽宁沈阳110032

出　　处：《中草药》2021年第18期5688-5696,共9页Chinese Traditional and Herbal Drugs

基　　金：广东省自然科学基金项目(2021A1515011485);广东省教育厅创新强校工程项目(2018KQNCX350);吉林大学珠海学院创新强校工程项目国外引进博士科技创新团队项目(2018KCTD03)。

摘　　要：目的基于文献报道,回顾总结中医古方辨证治疗前列腺癌的临床应用情况,为进一步开展古方治疗前列腺癌现代临床应用及其药效学机制研究提供指导。方法通过中国全文期刊数据库(CNKI)、维普中文期刊服务平台、万方数据知识服务平台,将检索时间限定为自建库到2020年7月4日,查阅中医或中西医结合运用古方辨证治疗前列腺癌的相关文献并追溯综述类文章,将涉及的古方与对应证型的名称规范化并按功能分类整理方剂,运用SPSS26.0软件对不同古方治疗前列腺癌的使用频数进行分析,运用Cytoscape软件对古方-功能类别-证型的复杂网络进行可视化分析。结果从3大数据库中共检索到中医古方治疗前列腺癌相关不重复文献共2025篇,依据研究目的共纳入医家经验38篇,病例报道14篇。证型规范后有34种,湿热蕴结证最常见,频率为10.7%,其次是肝肾阴虚证和瘀血内阻证,频率皆为8.4%,气血两虚证频率为7.6%。共得到古方64种,功能类别以补益剂、祛湿剂和理血剂为主,单个古方使用频率由高到低依次为六味地黄丸8.3%、八正散7.7%、知柏地黄丸5.9%、肾气丸4.1%、四君子汤4.1%等。古方-功能类别-证型的网络分析亦证实这一结论,六味地黄丸在网络中的关联程度最高,方剂对应的证型多为肝肾阴虚证、瘀血内阻证、湿热蕴结证等。结论通过对中医古方治疗前列腺癌的临床经验的梳理和总结可为古方治疗前列腺癌现代临床应用提供参考和指导,但其药效学机制仍需深入探究。Objective Based on the reported literatures,to review and summarize the application of ancient herbal formula in the dialectical treatment of prostate cancer by TCM,and provide a guidance for further researches on modern clinical applications and pharmacodynamic mechanisms against prostate cancer.Methods To search“treatments of prostate cancer with ancient herbal formula by Traditional Chinese Medicine”or“treatments of prostate cancer with ancient herbal formula by combination methods of Traditional Chinese and Western Medicine”in the databases of CNKI,VIP and Wan-fang,and trace the references of review articles.The search time was limited from database creation to July 4,2020.We standardized the names of the ancient prescriptions and corresponding syndromes.The prescriptions were classified according to their functions.Frequency analysis was used to analyze the usage of different ancient prescriptions in the treatment of prostate cancer by SPSS26.0 software.Results The network on prescription-functional category-syndrome type was constructed with Cytoscape software.A total of 2025 articles were retrieved from the three databases.According to our research purpose,38 medical experiences and 14 case reports were collected.There are 34 syndromes after our specifications,in which the damp-heat syndrome is the most common one,with a frequency rate of 10.7%,the liver-kidney Yin deficiency syndrome and blood stasis resistance syndrome followed by,both with a frequency of 8.4%,and the frequency of qi-blood deficiency syndrome is 7.6%.A total of 64 kinds of ancient prescriptions were obtained.The functions are mainly about the tonic,dampness-removing and blood-regulating recipes.The frequencies from high to low are pill of six ingredients with rehmannia 8.3%,Bazheng powder 7.7%,Zhibai Dihuang pill 5.9%,Shenqi pill 4.1%,Sijunzi decoction 4.1%,etc.The results of network analysis on ancient prescription-functional category-syndrome type also confirmed the conclusion,which is that the pill of six ingredients with rehm

关 键 词：前列腺癌 中医古方 功能类别 证型 临床应用 

分 类 号：R287[医药卫生—中药学]