补阳还五汤治疗动脉粥样硬化的物质基础及作用机制研究进展  

Research Progress on the Material Foundation and Mechanism of Buyang Huanwu Decoction in the Treatment of Atherosclerosis

作　　者：尤心怡 王文凤 徐霞 张文彤 房文洁 谭志伟 姜丽[1,3,4] YOU Xinyi;WANG Wenfeng;XU Xia;ZHANG Wentong;FANG Wenjie;TAN Zhiwei;JIANG Li(Research Center for Differentiation and Development of TCM Basic Theory,Jiangxi University of Chinese Medicine,Nanchang 330004 Jiangxi,China;Ji'an Food and Drug Inspection and Testing Center,Ji'an 343000 Jiangxi,China;Jiangxi Provincial Key laboratory of TCM etiopathogenisis,Nanchang 330004 Jiangxi,China;Key Laboratory of Pharmacology of Traditional Chinese Medicine in Jiangxi,Nanchang 330004 Jiangxi,China)

机构地区：[1]江西中医药大学中医基础理论分化发展研究中心,江西南昌330004 [2]江西省吉安市食品药品检验所,江西吉安343000 [3]江西省中医病因生物学重点实验室,江西南昌330004 [4]江西省中药药理学重点实验室,江西南昌330004

出　　处：《中药新药与临床药理》2021年第10期1575-1581,共7页Traditional Chinese Drug Research and Clinical Pharmacology

基　　金：国家自然科学基金青年项目(81703823);江西省自然科学基金项目(20192BAB205110)。

摘　　要：补阳还五汤的主要有效成分有黄芪甲苷、芍药苷、苦杏仁苷、山柰素等,具有补气、活血、通络的功效。补阳还伍汤作为中医经典的益气活血方剂,活血而不伤正,是治疗气虚血瘀证的常用复方,在动脉粥样硬化的防治方面有较好的疗效。该文从抗炎和抗氧化应激角度,对补阳还五汤治疗动脉粥样硬化的相关物质基础及作用机制进行综述,以期为补阳还五汤在心脑血管疾病的临床应用提供一定的参考。The main effective components of Buyang Huanwu Decoction(BYHWD)are astragaloside IV,paeoniflorin,amygdalin,kaempferol,etc.,which have the effects of supplementing qi,activating blood and dredging collaterals.BYHWD can activate blood without damaging the body,which is a commonly used prescription in the treatment of qi-deficiency and blood-stasis,and has good curative effect in the prevention and treatment of atherosclerosis.In this paper,the material foundation and mechanism of BYHWD in the treatment of atherosclerosis based on anti-inflammation and anti-oxidative stress were summarized,providing theoretical reference for the clinical application of BYHWD in the treatment of cardiovascular and cerebrovascular diseases.

关 键 词：补阳还五汤 动脉粥样硬化 抗炎 抗氧化应激 物质基础 作用机制 

分 类 号：R285.5[医药卫生—中药学]