PEG-IFN α-2a联合恩替卡韦治疗慢性乙型肝炎的效果及对患者免疫功能的影响  

Effect of PEG-IFN α-2a combined with entecavir in the treatment of chronic hepatitis B and its influence on the immune function of patients

作　　者：常晋芳[1] CHANG Jinfang(No.4 Liver Disease Department,the third People's Hospital of Taiyuan,Taiyuan 030012,China)

机构地区：[1]太原市第三人民医院肝病四科,山西太原030012

出　　处：《临床医学研究与实践》2021年第29期62-64,共3页Clinical Research and Practice

摘　　要：目的探讨聚乙二醇干扰素(PEG-IFN)α-2a联合恩替卡韦治疗慢性乙型肝炎(CHB)的效果及对患者免疫功能的影响。方法回顾性选取2014年6月至2017年6月我院收治的60例CHB患者为研究对象,依据治疗方法将其分为联合治疗组和单独治疗组,各30例。联合治疗组采用PEG-IFNα-2a联合恩替卡韦治疗,单独治疗组采用恩替卡韦治疗。比较两组的HBV抗原抗体检测结果、肝功能指标、免疫功能指标、不良反应发生情况。结果联合治疗组的HBsAg、HBeAg转阴率,HBV DNA转阴率,抗-HBs、抗-HBe阳性率均显著高于单独治疗组,差异具有统计学意义(P<0.05)。治疗后,两组的血清ALT、AST、GGT、TBIL水平均降低,且联合治疗组低于单独治疗组,差异具有统计学意义(P<0.05)。治疗后,两组的CD3^(+)、CD4^(+),补体C3、C4水平均升高,CD8^(+)均降低,且联合治疗组优于单独治疗组,差异具有统计学意义(P<0.05)。联合治疗组的不良反应总发生率,低于单独治疗组,差异具有统计学意义(P<0.05)。结论PEG-IFNα-2a联合恩替卡韦治疗CHB的效果比单独采用恩替卡韦治疗的效果更好,更能有效提升患者的免疫功能。Objective To explore the effect of polyethylene glycol interferon(PEG-IFN)α-2a combined with entecavir in the treatment of chronic hepatitis B(CHB)and its influence on the immune function of patients.Methods Sixty patients with CHB treated in our hospital from June 2014 to June 2017 were retrospectively selected as the research objects.According to the treatment methods,the patients were divided into combined treatment group and separate treatment group,with 30 cases in each group.The combined treatment group was treated with PEG-IFNα-2a combined with entecavir,and the separate treatment group was treated with entecavir.The HBV antigen antibody test results,liver function indexes,immune function indexes and adverse reactions were compared between the two groups.Results The negative rates of HBsAg,HBeAg,HBV DNA positive rates,anti-HBs and anti-HBe in the combined treatment group were significantly higher than those in the separate treeatmnt group,and the differences were statistically significant(P<0.05).After treatment,the levels of serum ALT,AST,GGT and TBIL of both groups decreased,and those in the combined treatment group were lower than the separate treatment group,and the differences were statistically significant(P<0.05).After treatment,the CD3^(+),CD4^(+)and complement C3 and C4 of both groups increased,the CD8^(+)decreased,and those in the combined treatment group were better than the separate treatment group,and the differences were statistically significant(P<0.05).The total incidence of adverse reactions in the combined treatment group was lower than that in the separate treatment group,and the difference was statistically significant(P<0.05).Conclusion The PEG-IFN α-2a combined with entecavir in the treatment of CHB has better effect compared with entecavir alone,and it can effectively improve the immune function of patients.

关 键 词：慢性乙型肝炎 聚乙二醇干扰素Α-2A 恩替卡韦 

分 类 号：R512.62[医药卫生—内科学]