酸浆全草甾体类化学成分研究  

Studies on the steroids from the whole herb of Physalis alkekengi var.franchetii

作　　者：谭茂强 牛峥 张敏[1,2] 郭远强 邱峰[1,2] 丁丽琴[2] TAN Mao-qiang;NIU Zheng;ZHANG Min;GUO Yuan-qiang;QIU Feng;DING Li-qin(School of Chinese Materia Medica,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;State Key Laboratory of Component-based Chinese Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;College of Pharmacy,Nankai University,Tianjin 300350,China)

机构地区：[1]天津中医药大学中药学院,天津301617 [2]天津中医药大学组分中药国家重点实验室,天津301617 [3]南开大学药学院,天津300350

出　　处：《中草药》2021年第17期5203-5209,共7页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金重点项目(82030116);国家自然科学基金面上项目(21472138)。

摘　　要：目的研究酸浆属植物酸浆Physalis alkekengi var. franchetii的化学成分。方法对酸浆全草醋酸乙酯部位采用硅胶、Sephadex LH-20、ODS等多种柱色谱,并结合制备液相等方法进行分离和纯化,根据理化性质及波谱数据对其化学成分进行结构鉴定。结果从酸浆醋酸乙酯部位中共分离鉴定10个化合物,分别为4β-methoxy-7β-hydroxyneophysalin B(1)、酸浆苦素P(2)、7-氧代-β-谷甾醇(3)、7β-羟基谷甾醇(4)、3β-羟基豆甾-5,22-二烯-7-酮(5)、豆甾-5,22-二烯-3β,7β-二醇(6)、(24R)-5,28-stigmastadiene-3β,24-diol-7-one(7)、(24S)-5,28-stigmastadiene-3β,24-diol-7-one(8)、3β-羟基-胆甾-5-烯-7-酮(9)、sargassuol A(10)。结论化合物1为新化合物4β-methoxy-7β-hydroxyneophysalin B,中文俗名酸浆苦素ⅩⅢ,化合物3~10均为首次从该属植物中分离得到。Objective To study the chemical constituents from Physalis alkekengi L.var.franchetii(Mast.)Makino.Methods The compounds were isolated and purified by comprehensive column chromatography and preparative RP-HPLC.Their structures were elucidated by physicochemical properties and spectral analyses.Results 10 compounds were obtained and identified as 4β-methoxy-7β-hydroxyneophysalin B(1),physalin P(2),7-oxo-β-sitosterol(3),7β-hydroxysitosterol(4),3β-hydroxystigmasta-5,22-dien-7-one(5),stigmast-5,22-dien-3β,7β-diol(6),(24R)-5,28-stigmastadiene-3β,24-diol-7-one(7),(24S)-5,28-stigmastadiene-3β,24-diol-7-one(8),3β-hydroxy-cholest-5-en-7-one(9),sargassuol A(10).Conclusion Compound 1 was a new compound.Compounds 3—10 were isolated from the Physalis genus for the first time.

关 键 词：酸浆全草 4β-methoxy-7β-hydroxyneophysalin B 酸浆苦素P 7-氧代-β-谷甾醇 结构鉴定 甾体类化合物 

分 类 号：R284.1[医药卫生—中药学]