肺癌患者血清维生素C水平与免疫功能及呼吸道病原菌感染的相关性研究  

Correlations of serum vitamin C with immune function and respiratory pathogen infection in patients with Lung cancer

作　　者：张艳 杨德平 金慧敏 郑江花 ZHANG Yan;YANG Deping;JIN Huimin;ZHENG Jianghua(Department of Laboratory Medicine,Zhoupu Hosipital Affiliated of Shanghai Health Medicine College,Shanghai 201318,China)

机构地区：[1]上海健康医学院附属周浦医院医学检验科,上海201318

出　　处：《检验医学与临床》2021年第20期2933-2936,共4页Laboratory Medicine and Clinic

基　　金：国家自然科学基金面上项目(81372318);上海市浦东新区卫生和计划生育委员会领先人才培养计划(PWRL2017-07)。

摘　　要：目的探讨肺癌患者血清维生素C(Vit C)水平与免疫功能及呼吸道病原菌感染的相关性。方法选取2016年1月至2020年10月该院收治的60例非小细胞肺癌患者作为研究组,其中肺腺癌患者39例(肺腺癌组),肺鳞癌患者21例(肺鳞癌组)。另选取同期该院体检健康者100例作为对照组。比较各组血清Vit C水平、免疫功能相关指标的差异,分析血清Vit C水平与肺癌呼吸道病原菌感染率的相关性。结果研究组患者血清Vit C水平明显低于对照组,差异有统计学意义(P<0.05);肺腺癌组与肺鳞癌组患者血清Vit C水平差异无统计学意义(P>0.05)。研究组患者补体C3、IgG和IgM的水平明显低于对照组,差异有统计学意义(P<0.05);肺腺癌组与肺鳞癌组患者补体C3、C4、IgG、IgM和IgA水平差异均无统计学意义(P>0.05);研究组患者血清Vit C水平与补体C3、IgG和IgM水平呈正相关(P<0.001)。血清Vit C水平与肺癌患者发生呼吸道病原菌感染的点二列相关系数为-0.486(P<0.001)。结论肺癌患者血清Vit C水平较健康人低,可能与其机体免疫功能降低、呼吸道病原菌感染率增加有关。Objective To investigate the correlation between serum vitamin C(Vit C)level with immune function and respiratory pathogenic infection in patients with lung cancer.Methods A total of 60 patients with non-small cell lung cancer admitted to the hospital from January 2016 to October 2020 were selected as the study group,including 39 patients with lung adenocarcinoma(lung adenocarcinoma group)and 21 patients with lung squamous cell carcinoma(lung squamous cell carcinoma group).In addition,100 healthy subjects were selected as the control group.The serum Vit C level and immune function related indexes were compared among all groups,and the correlation between serum Vit C level and respiratory tract pathogenic bacteria infection rate was analyzed.Results The serum Vit C level in the study group was significantly lower than that in the control group,the difference was statistically significant(P<0.05).There was no significant difference on serum Vit C level between lung adenocarcinoma group and lung squamous cell carcinoma group(P>0.05).The levels of C3,IgG and IgM in the study group were significantly lower than those in the control group,with statistical significance(P<0.05).There was no significant differences on the levels of C3,C4,IgG,IgM and IgA between lung adenocarcinoma group and lung squamous cell carcinoma group(P>0.05).The levels of serum Vit C in the study group was significantly correlated with the levels of C3,IgG and IgM(P<0.001).The point biserial correlation coefficient between serum Vit C level and lung cancer respiratory tract pathogen infection was-0.486(P<0.001).Conclusion The serum Vit C level of lung cancer patients was lower than that of healthy people,which might related to the decrease of immune function and the increase of infection rate of respiratory pathogens.

关 键 词：肺癌 维生素C 免疫球蛋白 呼吸道病原菌 

分 类 号：R563.1[医药卫生—呼吸系统] R446.5[医药卫生—内科学]