某儿童医院住院小婴儿感染病原体及多重耐药菌分析  

Analysis of Pathogens and Multidrug-Resistant Organisms in Hospitalized Infants from a Children’s Hospital

作　　者：李雪琴 王江涛[1] 赵爱玲 谷惠茹[1] 王晓玲[1] 郝小会 刘榕 王勤[1] Li Xueqin;Wang Jiangtao;Zhao Ailing;Gu Huiru;Wang Xiaoling;Hao Xiaohui;Liu Rong;Wang Qin(Children’s Hospital Affiliated to Zhengzhou University,Henan Children’s Hospital,Zhengzhou Children’s Hospital,Henan Zhengzhou 450018,China)

机构地区：[1]郑州大学附属儿童医院,河南省儿童医院,郑州儿童医院,河南郑州450018

出　　处：《儿科药学杂志》2021年第10期44-46,共3页Journal of Pediatric Pharmacy

基　　金：河南省医学科技攻关计划联合共建项目,编号LHGJ20190905。

摘　　要：目的:分析我院1~3月龄住院婴儿感染的病原菌分布及多重耐药情况。方法:回顾性收集2015年1月至2019年6月在我院小婴儿病区住院的1~3月龄感染婴儿的各类标本,统计分析病原菌及多重耐药菌的检出率等。结果:共收集送检标本23217份,3531份(15.2%)检出病原菌,阳性标本主要是痰培养标本(3284份)和血培养标本(178份),各年度病原菌检出率分别为2015年8.3%、2016年13.3%、2017年15.8%、2018年18.1%,逐年升高(P<0.05)。检出率排名前5位的病原菌依次为流感嗜血杆菌、金黄色葡萄球菌、大肠埃希菌、肺炎克雷伯菌、卡他莫拉菌;排名前5位的多重耐药菌依次为产超广谱β-内酰胺酶菌株、耐甲氧西林金黄色葡萄球菌、碳青霉烯类耐药肠杆菌、耐甲氧西林凝固酶阴性葡萄球菌、耐甲氧西林表皮葡萄球菌,各年度这5种多重耐药菌总检出率分别为2015年3.0%、2016年3.7%、2017年3.2%、2018年2.9%,差异无统计学意义(P>0.05)。结论:我院小婴儿病区感染送检标本主要是痰培养标本,病原菌检出率逐年上升,以革兰阴性菌为主,存在多重耐药现象。Objective:To analyze the distribution of pathogens and multidrug-resistant organisms in hospitalized infants aged from 1 to 3 months in our hospital.Methods:Retrospective analysis was performed on all kinds of specimens from infected infants aged from 1 to 3 months who were admitted into infant ward of our hospital from Jan.2015 to Jun.2019.The detection rates of pathogens and multidrug-resistant organisms were statistically analyzed.Results:A total of 23,217 specimens were collected and sent for examination,3,531 pathogens(15.2%)were detected,and the positive specimens were mainly sputum culture specimens(3,284 specimens)and blood culture specimens(178 specimens).The detection rates of pathogens were 8.3%in 2015,13.3%in 2016,15.8%in 2017 and 18.1%in 2018,increasing year by year(P<0.05).The top five pathogens ranked by the detection rate were respectively Haemophilus influenzae,Staphylococcus aureus,Escherichia coli,Klebsiella pneumoniae and Moraxella catarrhalis.The top five multidrug-resistant organisms ranked by the detection rate were respectively extended-spectrumβ-lactamase,methicillin-resistant S.aureus,carbapenem-resistant Enterobacteriaceae,methicillin-resistant coagulase negative Staphylococci and methicillin-resistant Staphylococcus epidermidis,with detection rate of 3.0%in 2015,3.7%in 2016,3.2%in 2017 and 2.9%in 2018(P>0.05).Conclusion:Infection specimens from the infant ward of our hospital are mainly sputum culture specimens,and the detection rate of pathogens is increasing year by year,mainly for Gram-negative bacteria,with multidrug resistance.

关 键 词：婴儿 病原菌 多重耐药菌 感染 分布 

分 类 号：R725.1[医药卫生—儿科]