子宫内膜容受性影响因素的研究进展  

Latest research advances on factors that influence endometrial receptivity

作　　者：陈子江[1,2,3,4] 颜军昊 CHEN Zijiang;YAN Junhao(Center for Reproductive Medicine,Cheeloo College of Medicine,Shandong University,Jinan 250001,Shandong,China;Shandong Provincial Clinical Medicine Research Center for Reproductive Health,Shandong University,Jinan 250001,Shandong,China;National Research Center for Assisted Reproductive Technology and Reproductive Genetics,Shandong University,Jinan 250021,Shandong,China;Center for Reproductive Medicine,Renji Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China)

机构地区：[1]山东大学生殖医学研究中心,山东济南250001 [2]山东省生殖健康临床医学研究中心,山东济南250001 [3]国家辅助生殖与优生工程技术研究中心,山东济南250021 [4]上海交通大学医学院附属仁济医院生殖中心,上海200127

出　　处：《山东大学学报（医学版）》2021年第8期1-7,共7页Journal of Shandong University:Health Sciences

基　　金：国家重点研发计划(2016YFC1000604)。

摘　　要：子宫内膜容受性,是指子宫内膜对胚胎的接受能力。良好的子宫内膜状态是成功妊娠的关键,而在整个月经周期中仅在种植窗期内膜才拥有良好的容受性。据报道,约有2/3的胚胎植入失败或妊娠丢失归咎于子宫内膜的原因。因此,针对引起不良子宫内膜容受性的因素及具体机制的研究,将有助于及时诊断并有效治疗相关不孕疾病,改善妊娠结局。综述影响子宫内膜容受性的多种因素,以期为深入研究子宫内膜容受性的生理病理机制提供思路。Good endometrial condition is essential to successful pregnancy. Endometrial receptivity, the capability of endometrium to receive embryo, will improve during the window of implantation in menstruation cycle, indicating the accurate time for implantation. As reported, 2/3 cases on embryo implantation failure or pregnancy loss were attributed to endometrial dysfunction. Evidence based on studies about bad endometrial receptivity and exact mechanism thereof, will provide effective approaches for diagnosis and treatment of these dysfunctions. In this review, we elaborated multiple underlying factors that influence endometrial receptivity, hoping to provide reference for further studies on pathophysiological mechanisms of endometrium in embryo implantation failure or pregnancy loss.

关 键 词：子宫内膜容受性 解剖因素 免疫因素 代谢因素 内分泌因素 

分 类 号：R711.32[医药卫生—妇产科学]