NK细胞参与子宫内膜异位症及其不孕的分子机制  

Molecular mechanisms of NK cells involved in endometriosis and its associated infertility

作　　者：单婧 王晓秋[1] 李大金[1] SHAN Jing;WANG Xiaoqiu;LI Dajin(Institute of Obstetrics and Gynecology Hospital of Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院研究所,上海200090

出　　处：《山东大学学报（医学版）》2021年第8期8-13,共6页Journal of Shandong University:Health Sciences

基　　金：国家自然科学基金(81971456,32070915)。

摘　　要：NK细胞作为机体免疫系统的第一道防线,参与多种自身免疫性疾病、感染性疾病以及肿瘤等疾病的发生发展。不同活化状态的NK细胞具有不同的免疫效应,与疾病的转归密切相关。子宫内膜异位症(EMS)是一种常见的妇科疾病,虽为良性病变,但子宫内膜异位种植生长的特性与肿瘤相似,且受损的在位子宫内膜与胚胎着床失败相关,是EMS相关不孕的重要病因。虽然目前已明确异位灶微环境免疫失调是促进异位灶种植生长的重要因素,且NK细胞是异位灶异常免疫微环境形成的关键细胞,但深入的致病机制及其在位子宫内膜损伤的分子机制仍然知之甚少。本文梳理了近年来NK细胞参与EMS发病的相关研究,以期更好地理解EMS及EMS相关不孕的发病机制,为EMS的防治及EMS相关不孕的诊治提供新思路。As the first line of defense of the immune system, NK cells are involved in the occurrence and development of a variety of autoimmune diseases, infectious diseases, and tumors. NK cells in different states of activation have different functions, which are closely related to the outcome of the disease. Although endometriosis(EMS) is a common and benign gynecological disease, the growth characteristics of ectopic foci are similar to tumors, and the damaged eutopic endometrium is associated with abnormal embryo implantation, which is an important cause of EMS-related infertility. Although it has been established that the abnormal immune microenvironment is an important factor promoting the growth of ectopic foci, and NK cells are the key cells in ectopic milieu, the in-depth functional regulation mechanism and its potential role played in endometrial injury are still poorly understood. This article updates the research progress of NK cells in the pathogenesis of EMS, in order to provide better understanding of the pathogenesis of EMS and EMS-related infertility, and new ideas for the prevention, diagnosis and treatment of EMS and EMS-related infertility.

关 键 词：NK细胞 子宫内膜异位症 异位灶微环境 不孕 

分 类 号：R711.71[医药卫生—妇产科学]