二苯醚类双膦配体合成及工艺优化  

Synthesis and Process Optimization of Diphenyl Ether Bisphosphine Ligands

作　　者：吴红英 化林[2] 陈辉[2] 赵顺伟[2] 刘婷婷 Wu Hongying;Hua Lin;Chen Hui;Zhao Shunwei;Liu Tingting(The Boiler&Pressure Vessel Safety Inspection Institute of Henan Province,Zhengzhou 450016,China;Institute of Chemistry Co.Ltd.,Henan Academy of Sciences,Zhengzhou 450002,China)

机构地区：[1]河南省锅炉压力容器安全检测研究院,河南郑州450016 [2]河南省科学院化学研究所有限公司,河南郑州450002

出　　处：《山东化工》2021年第18期36-37,41,共3页Shandong Chemical Industry

基　　金：国家自然科学基金(22001060);河南省青年托举人才项目(2021HYTP005);河南省科学院科研开发项目(200403001,200503001,200603108,210203026,210603011,210403023,210503001)。

摘　　要：二苯醚类双膦配体在有机催化领域应用广泛,因此探索此类配体的高效合成,具有重要研究意义。本文以二苯醚为原料,经正丁基锂锂化后,再与二苯基氯化膦反应,合成了具有不同取代基的二苯醚类双膦配体,如2,2′-双(二环己基膦基)二苯醚、2,2′-双(二异丙基膦基)二苯醚。并进一步探索了反应过程中时间、温度、反应物物质的量比等对最终反应收率的影响,以便高效的合成二苯醚类双膦配体。As diphenyl ether bisphosphine ligands are widely applied in organic catalysis,it is of important research significance to explore the efficient synthesis of such ligands.In this paper,diphenyl ether is used as the raw material,and reacted with diphenyl phosphine chloride after n-butyl lithium lithiation to synthesize diphenyl ether bisphosphine ligands with different substituents,such as 2,2'-bis(dicyclohexylphosphino)diphenyl ether,2,2'-bis(diisopropylphosphino)diphenyl ether.The influences of time,temperature,molar ratio of reactants during the reaction process were explored to improve the yield of diphenyl ether bisphosphine ligands.

关 键 词：膦配体 二苯醚 锂化 环己基 异丙基 

分 类 号：O627.6[理学—有机化学]