Recent advances in hydrogel-based anti-infective coatings  

作　　者：Mengjing Fu Yijing Liang Xue Lv Chengnan Li Yi Yan Yang Peiyan Yuan Xin Ding 

机构地区：[1]School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Shenzhen,518107,China [2]Institute of Bioengineering and Nanotechnology,31 Biopolis Way,Singapore,138669,Singapore

出　　处：《Journal of Materials Science & Technology》2021年第26期169-183,共15页材料科学技术（英文版）

基　　金：financially supported by the National Natural Science Foundation of China(Nos.81803481,81830103 and 31900982);the Shenzhen Science and Technology Program(Nos.KQTD20190929173853397 and JCYJ20200109142401698);the Fundamental Research Funds for the Central Universities of China(Nos.20ykpy123 and 19ykpy142);the Institute of Bioengineering and Nanotechnology(Biomedical Research Council,Agency for Science,Technology and Research,Singapore)(Nos.SC 19/08-101002)。

摘　　要：Bacterial infections associated with biomedical devices and implants have posed a great challenge to global healthcare systems.These infections are mainly caused by bacterial biofilm formed on the surface of biomaterials,protecting the encapsulated bacteria from conventional antibiotic treatment and attack of the immune system.As the bacterial biofilm is difficult to eradicate,bactericidal and antifouling coatings have emerged as promising strategies to prevent biofilm fo rmation and subsequent infections.Hydrogels with three-dimensional crosslinked hydrophilic networks,tunable mechanical property and large drugloading capacity are desirable coating materials,which can kill bacteria and/or prevent bacterial adhesion on the surface,inhibiting biofilm formation.Herein,we review recent developments of hydrogels as anti-infective coatings.Particularly,we highlight two chemical approaches(graft-from and graft-to),which have been used to immobilize hydrogels on surfaces,and present advances in the development of bactericidal(contact-killing and antimicrobial-releasing),antifouling(hydrophilic polymer network)and bifunctional hydrogel coatings with both bactericidal and antifouling activities.In addition,the challe nges of hydrogel coatings for clinical applications are discussed,and future research directions of anti-infective hydrogel coatings are proposed.

关 键 词：BIOFILM HYDROGEL Coating ANTIFOULING BACTERICIDAL 

分 类 号：TB306[一般工业技术—材料科学与工程]