动脉粥样硬化斑块乏氧PET成像研究进展  

Research progresses of PET in hypoxia imaging of atherosclerosis plaques

作　　者：谷珊珊 卢洁[1,2] GU Shanshan;LU Jie(Department of Radiology and Nuclear Medicine,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100053 [2]磁共振成像脑信息学北京市重点实验室,北京100053

出　　处：《中国医学影像技术》2021年第10期1583-1586,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(81974261)。

摘　　要：动脉粥样硬化(AS)易损斑块破裂是导致急性心脑血管事件的主要原因。AS易损斑块形成的主要机制包括炎症、微钙化、乏氧及新生血管形成等。借助特异的放射性分子探针,PET显像能准确识别易损斑块形成过程中的关键靶点,为相关诊疗提供途径。本文就AS易损斑块乏氧PET显像研究进展进行综述。The majority of acute cardiovascular and cerebrovascular events result from sudden rupture of vulnerable plaques in atherosclerosis(AS).The formation process of AS vulnerable plaques mainly includes inflammation,microcalcification,hypoxia and neoangiogenesis.With the help of specific radiolabeled probes,PET imaging can accurately identify the key targets in the formation process of vulnerable plaque,providing the means for diagnosis and treatment of AS vulnerable plaques.The research progresses of PET in hypoxia imaging of AS vulnerable plaques were reviewed in this paper.

关 键 词：动脉硬化 正电子发射断层显像 缺氧 斑块 

分 类 号：R816.2[医药卫生—放射医学] R445.5[医药卫生—临床医学]