环磷酰胺联合糖皮质激素在系统性红斑狼疮中的应用效果  

Effect of Cyclophosphamide combined with glucocorticoid in systemic lupus erythematosus

作　　者：刘玲[1] 汤艳华[1] 刘炬[1] LIU Ling;TANG Yan-hua;LIU Ju(Department of Rheumatism and Immunology,Jiujiang First People′s Hospital,Jiangxi Province,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院风湿免疫科,江西九江332000

出　　处：《中国当代医药》2021年第29期56-59,共4页China Modern Medicine

基　　金：江西省卫生计生委科技计划项目(20197111)。

摘　　要：目的探讨环磷酰胺联合糖皮质激素在系统性红斑狼疮(SLE)中的应用效果。方法选取2018年3月至2020年3月于九江市第一人民医院治疗的82例SLE患者,按随机数字表法分为观察组与对照组,每组各41例。对照组予以泼尼松治疗,观察组在对照组基础上加用环磷酰胺治疗。比较两组临床疗效、血清细胞因子水平、免疫球蛋白水平和不良反应发生情况。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组患者治疗前血清细胞因子水平、免疫球蛋白水平比较,差异无统计学意义(P>0.05);两组患者治疗后白介素-6(IL-6)、白介素-10(IL-10)、干扰素-α(IFN-α)、免疫球蛋白A(IgA)、免疫球蛋白M(IgM)和免疫球蛋白G(IgG)水平低于本组治疗前,差异有统计学意义(P<0.05);观察组治疗后IL-6、IL-10、IFN-α、IgA、IgM、IgG水平低于对照组,差异有统计学意义(P<0.05);两组不良反应总发生率比较,差异无统计学意义(P>0.05)。结论环磷酰胺联合泼尼松可提高SLE治疗效果,减轻机体炎症反应,抑制免疫过度亢进,稳定病情进展,安全可靠。Objective To explore the effect of Cyclophosphamide combined with glucocorticoid in systemic lupus erythematosus(SLE).Methods A total of 82 SLE patients treated in Jiujiang First People′s Hospital from March 2018 to March 2020 were divided into observation group and control group according to the random number table method,with 41 cases in each group.The control group was treated with Prednisone,and the observation group was treated with Cyclophosphamide on the basis of the control group.The clinical efficacy,serum cytokine level,immunoglobulin level and incidence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).There were no significant differences in serum cytokine levels and immunoglobulin levels between the two groups before treatment(P>0.05);after treatment,the interleukin-6(IL-6),interleukin-10(IL-10),interferon-α(IFN-α),immunoglobulin A(IgA),immunoglobulin M(IgM)and immunoglobulin G(IgG)levels of the two groups were lower than those before treatment,and the differences were statistically significant(P<0.05);after treatment,the levels of IL-6,IL-10,IFN-α,IgA,IgM,and IgG in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion Cyclophosphamide combined with Prednisone can enhance the therapeutic effect of SLE,reduce the body′s inflammatory response,suppress excessive immune hyperactivity,stabilize the progression of the disease,and is safe and reliable.

关 键 词：系统性红斑狼疮 环磷酰胺 糖皮质激素 血清细胞因子 不良反应 

分 类 号：R593.241[医药卫生—内科学]