紫癜性肾炎患者尿红细胞形态与中医证型的关系研究  

Research on the relationship between urinary red blood cell morphology and traditional Chinese medinine syndrome types in patients with purpuric nephritis

作　　者：罗立媛 钟英超 谢月恒 钟华文 LUO Li-yuan;ZHONG Ying-chao;XIE Yue-heng;ZHONG Hua-wen(The Second Department of Internal Medicine,Yangjiang Hospital of Traditional Chinese Medicine,Guangdong Province,Yangjiang529500,China)

机构地区：[1]广东省阳江市中医医院内二科,广东阳江529500

出　　处：《中国当代医药》2021年第29期153-156,共4页China Modern Medicine

基　　金：广东省阳江市医疗卫生类科技计划项目(SF2020101)。

摘　　要：目的观察紫癜性肾炎患者尿红细胞形态与中医证型的关系。方法选取2020年8月至2021年3月阳江市中医医院收治的100例紫癜性肾炎患者作为研究对象,采集患者10 ml新鲜中段晨尿,实施尿红细胞形态检查,结合患者舌象、脉象及证候特点对患者进行辨证分型,探究紫癜性肾炎患者尿红细胞形态与中医证型的关系。结果中医辨证分型显示,100例患者中风热搏结证20例(20.0%)、热毒内炽证12例(12.0%)、湿瘀互结证23例(23.0%)、气阴两虚证36例(36.0%)、脾肾阳虚证9例(9.0%);气阴两虚证患者异常红细胞百分比、棘形红细胞百分比均高于其他中医证型,差异有统计学意义(P<0.05);气阴两虚证异常红细胞含量百分比靶形红细胞>正红细胞>环形红细胞>其他>小红细胞>大红细胞>棘形红细胞,差异有统计学意义(P<0.05);湿瘀互结证环形红细胞百分比>正红细胞>小红细胞>靶形红细胞>大红细胞>其他>棘形红细胞,差异有统计学意义(P<0.05);风热搏结证异常红细胞含量百分比小红细胞>正红细胞>靶形红细胞>其他>环形红细胞>大红细胞>棘形红细胞,差异有统计学意义(P<0.05);脾肾阳虚证正红细胞形态含量百分比>其他>小红细胞>大红细胞>靶形红细胞>环形红细胞>棘形红细胞,差异有统计学意义(P<0.05);热度内炽证环形红细胞>正红细胞>其他>靶形红细胞>大红细胞>小红细胞>棘形红细胞,差异有统计学意义(P<0.05)。结论紫癜性肾炎患者中医证型以气阴两虚证居多,且中医证型不同异常红细胞含量百分比也呈现出明显差异,尿红细胞形态检测在中医辨证分型中有重要的参考意义。Objective To observe the relationship between urinary red blood cell morphology and traditional Chinese medinine(TCM)syndrome types in patients with purpuric nephritis.Methods A total of 100 patients with purpuric nephritis in Yangjiang Hospital of Traditional Chinese Medicine from August 2020 to March 2021 were selected as the research objects,10 ml of fresh mid-stage urine from the patients was collected,and urinary red blood cell morphology examination was performed,combined with the patient′s tongue,pulse,and syndrome characteristics.The patients were classified into syndrome differentiation,and the relationship between urinary red blood cell morphology and TCM syndrome types in patients with purpuric nephritis was explored.Results According to the differentiation of TCM syndromes,100 patients had apoplexy and heat stroke syndrome in 20 cases(20.0%),heat toxin internal burning syndrome in 12 cases(12.0%),dampness and blood stasis mutual syndrome in 23 cases(23.0%),Qi and Yin deficiency syndrome 36 cases(36.0%),9 cases(9.0%)of spleen and kidney yang deficiency syndrome;the percentage of abnormal red blood cells and the percentage of spiny red blood cells in patients with deficiency of both qi and yin syndrome were significantly higher than those of other TCM syndrome types,and the differences were statistically significant(P<0.05).The percentage of abnormal red blood cell content of Qi and Yin deficiency syndrome:target red blood cells>positive red blood cells>circular red blood cells>others>small red blood cells>macro red blood cells>spinous red blood cells,the comparison of red blood cell morphology,and the differences were statistically significant(P<0.05).The percentage of ring red blood cells in the syndrome of dampness and stasis>positive erythrocytes>small red blood cells>target erythrocytes>macro erythrocytes>others>spinous erythrocytes,and the differences were statistically significant(P<0.05).The percentage of abnormal erythrocyte content in wind-heat syndrome:small erythrocytes>erythrocytes>target

关 键 词：紫癜性肾炎 尿红细胞形态 中医证型 气阴两虚 

分 类 号：R692.34[医药卫生—泌尿科学]