某院送检女性患者泌尿生殖道样本生殖道病原体感染情况分析  

Analysis of genitourinary tract pathogen infection of female patients in a hospital

作　　者：王向荣 WANG Xiang-rong(Department of Clinical Laboratory,the First Affiliated Hospital of Fujian Medical University,Fujian Province,Fuzhou350005,China)

机构地区：[1]福建医科大学附属第一医院检验科,福建福州350005

出　　处：《中国当代医药》2021年第29期174-177,共4页China Modern Medicine

摘　　要：目的分析福建医科大学附属第一医院门诊及住院患者送检的女性生殖道病原体检测样本中病原体的感染情况。方法收集2020年12月至2021年2月福建医科大学附属第一医院门诊及住院患者送检的女性生殖道病原体核酸检测样本共417例,分析其生殖道病原体核酸检测结果及临床资料,病原体包括淋病奈瑟菌(NG)、沙眼衣原体(CT)、生殖支原体(MG)、人型支原体(MH)、单纯疱疹病毒Ⅱ型(HSV-Ⅱ)、解脲脲原体(UU)及微小脲原体(UP)七种,分析患者的感染情况。结果送检的417例患者中,病原体核酸阳性230例,占比55.2%。七种病原体核酸阳性率比较,差异有统计学意义(P<0.05),其中UP阳性率最高(38.1%)。不同年龄段女性患者病原体核酸阳性率比较,差异无统计学意义(P>0.05)。不同临床症状患者病原体核酸阳性率比较,差异有统计学意义(P<0.05),其中以妇科肿瘤和泌尿生殖系统感染的阳性率较高,阳性率分别为72.4%和71.3%。同时感染两种及以上病原体的女性82例,最多同时感染6种病原体。结论随着诊断技术的不断发展,分子诊断已普遍应用于临床,包括DNA检测和RNA检测等技术都为诊断这些病原体提供了更好的方法,能够为临床诊疗提供更丰富的信息,要重视女性生殖系统常见病原体的混合感染,加强预防和筛查。Objective To analyze the pathogen infection in female reproductive tract samples from outpatients and inpatients in the First Affiliated Hospital of Fujian Medical University.Methods A total of 417 female reproductive tract pathogens nucleic acid samples were collected from outpatients and inpatients of the First Affiliated Hospital of Fujian Medical University from December 2020 to February 2021,and the nucleic acid test results and clinical data of these samples were analyzed.The pathogens include Neisseria gonorrhoeae(NG),Chlamydia trachomatis(CT),Mycoplasma genitalium(MG),Mycoplasma hominis(MH),herpes simplex virus typeⅡ(HSV-Ⅱ),Ureaplasma urealyticum(UU)and Ureaplasma parvum(UP),the infection status of the patient were analyzed.Results Among 417 patients,230(55.2%)were positive for pathogen nucleic acid.The positive rate of nucleic acid of seven pathogens was statistically significant(P<0.05),and the positive rate of UP was the highest(38.1%).There was no significant difference in the positive rate of pathogen nucleic acid among female patients of different ages(P>0.05).The positive rate of pathogen nucleic acid in patients with different clinical symptoms was significantly different(P<0.05),among which the positive rate of gynecological tumor and urinary and reproductive system infection was higher,72.4%and 71.3%,respectively.Eighty-two women were infected with two or more pathogens at the same time,with a maximum of six pathogens at the same time.Conclusion With the continuous development of diagnostic technology,molecular diagnosis has been widely used in clinical practice,including DNA detection and RNA detection,which provide a better method for the diagnosis of these pathogens and can provide richer information for clinical diagnosis and treatment.It is necessary to pay attention to the mixed infection of common pathogens in the female reproductive system and strengthen prevention and screening.

关 键 词：生殖道感染 核酸检测 解脲脲原体 微小脲原体 

分 类 号：R446.12[医药卫生—诊断学]