三七抗血小板聚集及抗凝作用机制研究  

Study on Antiplatelet and Anticoagulant Mechanism of Sanqi

作　　者：朱心怡 王琪[1] 赵赟霄[1,2,3] 宋雅雅[1,2,3] 张威 赵益明 ZHU Xinyi;WANG Qi;ZHAO Yunxiao;SONG Yaya;ZHANG Wei;ZHAO Yiming(The First Affiliated Hospital of Soochow University,Suzhou 215006,China;Jiangsu Institute of Hematology;Key Laboratory of Thrombosis and Hemostasis,Ministry of health;Yancheng City First People's Hospital)

机构地区：[1]苏州大学附属第一医院,江苏苏州215006 [2]江苏省血液研究所 [3]卫生部血栓与止血重点实验室 [4]盐城市第一人民医院

出　　处：《西部中医药》2021年第8期21-24,共4页Western Journal of Traditional Chinese Medicine

摘　　要：目的:探讨中药三七抗血小板聚集和抗凝的作用机制。方法:征集10例志愿者,每日口服三七3 g,连续服用5日。比较服药前后经由胶原(collgen,COL)、肾上腺素(epinephrine,EPI)、二磷酸腺苷(adenosine diphosphate,ADP)和花生四烯酸(arachidonic acid,AA)所诱导的血小板聚集率(maximum platelet aggregation rate,MAR),比较血浆中血管性血友病因子抗原(von willebrand factor antigen,VWF:Ag)、P-选择素(Pselectin)含量,凝血酶时间(thrombin time,TT),活化部分凝血活酶时间(activated partial thromboplastin time,APTT)及凝血酶原时间(prothrombin time,PT)。结果:与服药前相比,MAR在第3、6日均显著下降(P<0.05),服药后第6日血浆VWF:Ag和P-选择素的含量显著下降(P<0.05),服药后第6日,TT、APTT、PT均延长(P<0.05)。结论:三七主要通过抑制血小板黏附、聚集和释放的作用起到抗血栓的作用,兼有抗凝作用。Objective:To discuss antiplatelet and anticoagulant mechanism of Sanqi(Panax notoginsengin).Methods:Ten volunteers were recruited and took Sanqi orally each day,for five days consecutively,to compare MAR induced by COL,EPI,ADP,and AA before and after medication,to compare the contents of P selectin and VWF:Ag,TT,APTT and PT.Results:Compared with before the medication,MAR lowered at the 3rd and 6th day after taking Sanqi notably(P<0.05).The contents of VWF:Ag and P selectin reduced notaly in the plasma at the 6th day after medication than these before the medication(P<0.05).TT,APTT and PT prolonged at the 6th day after medication(P<0.05).Conclusion:Sanqi could develop antithrombotic and anticoagulant effects through inhibiting platelet adhesion,aggregation and release.

关 键 词：三七 血小板 活化 聚集 抗凝 

分 类 号：R285[医药卫生—中药学]