基于星点设计-效应面法优化沙棘宫愈凝胶辅料配方  

Optimization of Adjuvant Formula of Shaji Gongyu Gel Based on Central Composite Design-Response Surface Methodology

作　　者：胡宗苗 邓颖颖 姚东风[3] 马丽[3] 张恩户[3] HU Zongmiao;DENG Yingying;YAO Dongfeng;MA Li;ZHANG Enhu(Health Institute of North Industries,Xi'an 710065,China;Xi'an Hancheng Maternity Hospital;Shaanxi University of Chinese Medicine)

机构地区：[1]兵器工业卫生研究所,陕西西安710065 [2]西安汉城妇产医院 [3]陕西中医药大学

出　　处：《西部中医药》2021年第8期51-55,共5页Western Journal of Traditional Chinese Medicine

基　　金：陕西省科技统筹创新工程计划项目(2013KTCL03-11);陕西省教育厅科研计划项目(13JS028)。

摘　　要：目的:用星点设计-效应面法优化沙棘宫愈凝胶配方。方法:以卡波姆-940、三乙醇胺、羟丙基-β-环糊精及甘油的用量为考察因素,以外观性状、成型性、离心稳定性、冷冻稳定性及高温稳定性为考察指标,采用星点设计-效应面法优化沙棘宫愈凝胶配方并进行验证。结果:沙棘宫愈凝胶辅料的最优配比为卡波姆-940用量1%、羟丙基-β-环糊精6.5%、甘油10%、三乙醇胺0.25%。效应面法优化处方的预测值和实测值偏差均小于5%。结论:星点设计-效应面法可用于沙棘宫愈凝胶剂制备工艺优化,所建立的模型预测性良好。Objective:To optimize the formula of adjuvant in Shaji Gongyu gel using central composite design-response surface methodology.Methods:The dose of carbomer-940,triethanolamine,HP-β-CD,glycerin and others were chosen as the investigation factors,the appearance,formability,centrifugal stability,freezing stability and high temperature stability were taken as the indexes,the formula of adjuvant in the gel were optimized using central composite design-response surface methodology,and verified.Results:The best proportions of the adjuvants in Shaji Gongyu gel are 1% of carbomer-940,6.5% of HP-β-CD,10% of glycerin and 0.25% of triethanolamine.The deviation between the predicted value and the measured value is less than 5% after optimized using central composite design-response surface methodology.Conclusion:Central composite designresponse surface methodology could be used for the optimization of the preparation process for Shaji Gongyu gel,and the model shows good predictability.

关 键 词：沙棘宫愈凝胶 星点设计-效应面法 卡波姆-940 羟丙基-Β-环糊精 

分 类 号：R283[医药卫生—中药学]