基于苯乙醇苷类成分的紫珠属药材鉴别  

Discrimination of Callicarpa Herbs Based on Phenylethanol Glycosides

作　　者：孙宜春 黄春跃[2] 李慧馨 马梦洁 胡晓[2] SUN Yichun;HUANG Chunyue;LI Huixin;MA Mengjie;HU Xiao(Sinopharm Group Tongjitang(Guizhou)Pharmaceutical Co.,Ltd,Guiyang 50009;State Key Lab.of New Drug and Pharmaceutical Progress,Shanghai Institute of Pharmaceutical Industry,China State Instiute of Pharmaceutical Industry,Shanghai 201203)

机构地区：[1]国药集团(贵州)同济堂制药有限公司,贵州贵阳550009 [2]中国医药工业研究总院上海医药工业研究院创新药物与制药工艺国家重点实验室,上海201203

出　　处：《中国医药工业杂志》2021年第9期1230-1236,共7页Chinese Journal of Pharmaceuticals

基　　金：国家科技重大专项(2018ZX09731-016)。

摘　　要：通过化学计量学方法,探讨苯乙醇苷类成分在紫珠属药材鉴别上的应用。对20批紫珠属药材进行指纹图谱分析,建立紫珠属不同药材的指纹图谱。相似度分析、聚类分析及主成分分析结果显示,紫珠属不同药材的苯乙醇苷类成分差异较大,连翘酯苷B、金石蚕苷、毛蕊花糖苷、samioside和异类叶升麻苷可作为区分不同药材的"指纹"化学成分。建立的方法简便、操作性强,可用于紫珠属药材的鉴别和质量控制。The application of phenylethanol glycosides in the identification of Callicarpa Herbs was explored through the method of chemometrics.Fingerprint analysis of twenty batches of Callicarpa Herbs was carried out,and the fingerprints of different Callicarpa samples were established.The results of similarity,hierarchical clustering and principal component analysis showed that the phenylethanol glycosides varied in different Callicarpa samples.It was concluded that forsythoside B,poliumoside,verproside,samioside and isoacteoside could be used as the marker ingredients to distinguish different Callicarpa herbs.The established method is simple and highly operable,which can be used for the identification and quality control of Callicarpa medicinal materials.

关 键 词：紫珠属 指纹图谱 聚类分析 主成分分析 苯乙醇苷类 

分 类 号：R917[医药卫生—药物分析学] O657.7[医药卫生—药学]