RNA methylation preserves ES cell identity by chromatin silencing of retrotransposons  

作　　者：Zhaofa Xu Annabel Ma Yongchao C.Ma 

机构地区：[1]Departments of Pediatrics,Neurology and Physiology,Northwestern University Feinberg School of Medicine,Ann&Robert H.Lurie Children’s Hospital of Chicago,Chicago,IL,USA

出　　处：《Signal Transduction and Targeted Therapy》2021年第8期2259-2260,共2页信号转导与靶向治疗（英文）

摘　　要：RNA methylation on N6-methyladenosine(m6A)and histone methylation are critical mechanisms regulating gene expression at epitranscriptomic and epigenetic levels,respectively.However,how RNA methylation modulates histone methylation,and in which biological processes,is unknown.In a recent study published in Nature,Liu et al.1 identified the critical roles of m6A and its reader YTHDC1 in mediating histone methylation and chromatin silencing of retrotransposon genes to preserve embryonic stem(ES)cell identity.

关 键 词：preserve identity. 

分 类 号：R392.2[医药卫生—免疫学]