The many faces of cGAS:how cGAS activation is controlled in the cytosol,the nucleus,and during mitosis  

作　　者：Anna-Maria Herzner Martin Schlee Eva Bartok 

机构地区：[1]Department of Cancer Immunology and Immune Modulation,Boehringer Ingelheim Pharma GmbH&Co.KG,Biberach an der RiB,Germany [2]lnstitute of Clinical Chemistry and Clinical Pharmacology,University Hospital,University of Bonn,Bonn,Germany [3]Unit of Experimental Immunology,Department of Biomedical Sciences,Institute of Tropical Medicine,Antwerp,Belgium

出　　处：《Signal Transduction and Targeted Therapy》2021年第8期2261-2263,共3页信号转导与靶向治疗（英文）

基　　金：This work is supported by the Deutsche Forschungsgemeinschaft(DFG,German Research Foundation)under German's Excellence Strategy-EXC2151_390873048 of which EB and MS are members.

摘　　要：In their recently published study in Science,Li et al.1 unravel how hyperphosphorylation and chromatin-tethering of the double-stranded(dsDNA)sensor cGAMP synthase(cGAS)prevent self DNA recognition during mitosis(Fig.1);providing important insight into how this innate immune sensor balances its essential function for pathogen defense against potential autoinflammation.

关 键 词：ACTIVATION sensor insight 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]