胰岛素泵治疗青少年及成人1型糖尿病的疗效及安全性  

Efficacy and safety of insulin pump in the treatment of adolescent and adult type 1 diabetes mellitus

作　　者：肖竹 高杰[1] 郭强 林垦[1] 龙全惠 张勤[1] XIAO Zhu;GAO Jie;GUO Qiang;LIN Ken;LONG Quanhui;ZHANG Qin(Department of Endocrinology,The First People's Hospital of Chengdu,Chengdu 610041,China)

机构地区：[1]成都市第一人民医院内分泌科,四川成都610041

出　　处：《西部医学》2021年第10期1513-1516,共4页Medical Journal of West China

摘　　要：目的探讨胰岛素泵治疗青少年及成人1型糖尿病(T1DM)的疗效及安全性。方法选取2017年6月~2019年6月我院内分泌科住院的60例(年龄≥14岁)T1DM患者为研究对象,随机分为观察组(胰岛素泵组)和对照组(胰岛素四针强化组),每组各30例。观察并比较两组患者治疗后的血糖控制、低血糖发生率情况,并分析比较治疗过程中两组患者的依从性和经济效益成本。结果观察组和对照组患者在基线时的糖尿病病程、年龄及血糖控制情况比较,差异均无统计学差异(P>0.05)。治疗后,观察组比对照组的血糖显著降低,差异具有统计学意义(P<0.05);观察组血糖达标所需时间明显短于对照组(P<0.05);观察组低血糖发生率显著低于对照组(P<0.05);观察组依从性显著优于对照组(P<0.05);观察组胰岛素日需求量显著低于对照组(P<0.05)。观察组血糖达标率显著高于对照组,多因素分析结果显示胰岛素注射遗漏次数和血糖监测频率是影响血糖达标的关键因素(P<0.05)。结论胰岛素泵治疗青少年及成人1型糖尿病患者的疗效和安全性优势明显,可在临床推广应用。Objective To study the efficacy and safety of insulin pump in the treatment of adolescent and adult type 1 diabetes mellitus.Methods 60 patients(greater than or equal to 14 years)with type 1 diabetes admitted to Department of Endocrinology from June 2017 to June 2019 were selected as the study subjects and randomly divided into experimental group(insulin pump group)and control group(insulin intensive treatment group).The blood glucose control and hypoglycemia incidence of the two groups after treatment were observed and compared,and the compliance and economic benefit cost of the two groups during the treatment were analyzed and compared.Results There was no significant difference in the course of diabetes,age and blood glucose control between the experimental group and the control group at baseline(P>0.05).After treatment,the blood glucose of the experimental group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).The time of blood glucose reaching the standard in the experimental group was significantly shorter than that in the control group(P<0.05).The incidence of hypoglycemia in the experimental group was significantly lower than that in the control group(P<0.05).The compliance in the experimental group was significantly better than that in the control group(P<0.05).The daily insulin demand in the experimental group was significantly lower than that in the control group(P<0.05).The blood glucose compliance rate of the experimental group was significantly higher than that of the control group.The results of multivariate analysis showed that the times of missing insulin injection and the frequency of blood glucose monitoring were the key factors affecting blood glucose compliance(P<0.05).Conclusion The efficacy and safety of insulin pump in the treatment of adolescent and adult patients with type 1 diabetes are outstandin.

关 键 词：1型糖尿病 胰岛素泵 胰岛素四针强化治疗 疗效 安全性 

分 类 号：R587.1[医药卫生—内分泌]