Pharmacological effects of volatileoil from Alpinia officinaruim in treating cardiovascular diseases  

作　　者：CHENG Wen-jing JING Yong-shuai ZHANG Dan-shen ZHENG Yu-guang WU Lan-fang 

机构地区：[1]College of Chemistry and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China [2]College of Pharmacology,Hebei University of Chinese Medicine,Shijiazhuang 050200,China

出　　处：《中国药理学与毒理学杂志》2021年第10期761-762,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：The S&T Program of Hebei Province(H2021423057)。

摘　　要：Galangal(Alpinia officinaruim Hance)is the rhizome of the perennial herb belonging to Zingiberaceae family.There are many active components in galangal,such as volatile oil,flavonoids,terpenoids,phenylpropanoids and glycosides,among which the content of volatile oil is higher.The bioactivities of galangal volatile oil on health effect includesanti-inflammatory,anti-hypertension,anti-oxidation and prevention of cardiovascular diseases.Cardiovascular disease(CVD)is a kind of diseases related to circulatory system,which is also called circulatory system diseases.Over the past decade,the number of people dying from CVD has increased by 12.5%worldwide,and it is now the leading cause of human death worldwide.Studies have shown that galangal volatile oil has good pharmacological effects in treating CVD.①Regulation of glucose and lipid metabolism:studies have found that abnormal lipid metabolism can lead to obesity,diabetes,CVD and other diseases.The serum total triglyceride(TG)content in liver and serum will increase in patients with abnormal fat metabolism.The results showed that the volatile oil of galangal could increase the excretion of neutral cholesterol,significantly reduce liver TG and serum TG,and thus regulate glucose and lipid metabolism,prevent lipid deposition and prevent CVD.②Improving insulin resistance(IR):inhibition of inflammatory cytokines such as IL^(-1),IL-6 activation and expression of TNF-α,improves IR,thereby protecting myocardium from IR-mediated damage.Through the establishment of endothelial cell injury model induced by high glucose in vitro,it was found that the volatile oil of galangal can significantly reduce the secretion of pro-inflammatory cytokines TNF-αand IL-8,and inhibit the expression of ICAM-1 and VCAM-1 induced by high glucose,suggesting that it has protective effect on endothelial dysfunction and inflammation induced by high glucose.③Regulate blood oxygenation:during acute myocardial hypoxia,the activity of free radical scavenging system is decreased,and oxygen free radic

关 键 词：Alpinia officinaruim essential oil Cardiovascular disease pharmacological effect 

分 类 号：R285[医药卫生—中药学]