Research progress in mulberry leaf polysaccharide in treating diabetic nephropathy  

作　　者：ZHANG Shi-lin JING Yong-shuai ZHANG Dan-shen ZHENG Yu-guang WU Lan-fang 

机构地区：[1]College of Chemistry and Pharmaceutical Engineering,Hebei University of Science and Technology,Shijiazhuang 050018,China [2]College of Pharmacy,Hebei University of Chinese Medicine,Shijiazhuang 050200,China

出　　处：《中国药理学与毒理学杂志》2021年第10期778-779,共2页Chinese Journal of Pharmacology and Toxicology

基　　金：The S&T Program of Hebei Province(H2021423057)。

摘　　要：Diabetic nephropathy(DN)is one of the most common complications of diabetes.It is an important cause of diabetes disability and death.DN is a systemic metabolic syndrome.In its pathogenesis,the interaction of various cell activities and a large number of cytokine biological activities,the activation of signal pathways and so on are involved in the development of DN.At present,the clinical treatment of DN is mainly Western medicine,but it has limitations such as strong toxicity,high side effects and poor compliance.Therefore,the discovery of natural anti-DN substances has also become an important means to treat DN.Mulberry leaves are the dry leaves of Morus alba L.It is not only a traditional Chinese medicine,but also a dual-purpose medicinal material for medicine and food.It has the effects of dispelling wind and clearing heat,cooling blood and brightening eyes,tonifying and so on.Mulberry leaf polysaccharide(MLP)is a kind of high molecular compound in mulberry leaves.It has many pharmacological effects,such as hypoglycemic,antioxidant,anti-stress,anti-virus and so on.Therefore,the pharmacological effects of mulberry leaf polysaccharides on diabetic nephropathy are reviewed in this paper,so as to provide references for further research and application.The pathogenesis of DN is complex,and the mechanism of renal injury has not been completely clarified.The current studies believe that DN is closely related to heredity,abnormal glucose metabolism,abnormal lipid metabolism,microcirculation disorder,cytokine action,oxidative stress and so on.Relevant studies show that the pharmacological effects of mulberry leaf polysaccharide in the prevention and treatment of DN mainly include:①Effect on transforming factor-β1(TGF-β1):TGF-β1 has become an important cytokine involved in the formation of renal fibrosis by regulating cell proliferation and differentiation and the production of extracellular matrix(ECM).MLP can significantly inhibit TGF-β1 protein,and then inhibit the synthesis of extracellular matrix by renal in

关 键 词：mulberry leaf polysaccharide diabetic nephropathy TGF-β1 insulin receptor substrate RESISTIN adipo⁃nectin receptor 1 

分 类 号：R259[医药卫生—中西医结合] R277.5[医药卫生—中医内科学]