Metabolic Control ofγδT Cell Function  

作　　者：Ziyu Meng Guangchao Cao Quanli Yang Hengwen Yang Jianlei Hao Zhinan Yin 

机构地区：[1]NHC Key Laboratory of Hormones and Development,Tianjin Key Laboratory of Metabolic Diseases,Tianjin Medical University Chu Hsien-I Memorial Hospital&Tianjin Institute of Endocrinology,Tianjin Medical University,Tianjin,China [2]Zhuhai Institute of Translational Medicine,Zhuhai People's Hospital Affiliated with Jinan University,Jinan University,Zhuhai,Guangdong,China [3]The Biomedical Translational Research Institute,Faculty of Medical Science,Jinan University,Guangzhou,Guangdong,China.

出　　处：《Infectious Microbes & Diseases》2021年第3期142-148,共7页感染微生物与疾病（英文）

基　　金：supported by the grants from the National Natural Science Foundation of China(31830021 and 32030036 to ZY,31970830 to JH,32070121 to HY,31800722 to ZM);grant from the Ministry of Science and Technology of China(2020YFA0803500 to ZY),and grant from the Zhuhai Science and Technology Innovation Bureau(ZH22036302200063PWC to ZY).

摘　　要：Metabolic change is associated with cell activities,such as signal transduction,cell differentiation,and cell cycle.In the pathogenesis of autoimmune diseases,abnormal activation of T cells is often accompanied by changes in their metabolism.Conversely,the changes of metabolites can also regulate the proliferation,differentiation,and function of T cells.As a bridge between innate and adaptive immune responses,γδT cells have unique biological characteristics and functions.However,the immunometabolic mechanism ofγδT cells has been a novel field for research in recent years.In this review,we summarize the influence of metabolic pathways and nutrients onγδT cell function,and metabolic features ofγδT cell subsets,which may provide new insights in interventions targetingγδT cells in disease control.

关 键 词：γδT cells immunometabolism GLUCOSE fatty acid amino acid VITAMINS plant extract 

分 类 号：R392[医药卫生—免疫学]