二卤海因催化制备苯甲酸甲酯的方法探讨  

Preparation of Methyl Benzoate with DBDMH and DCDMH as Catalysts

作　　者：郑祖彪[1] 董召营 储新月 陈方媛 韩冰冰[1] Zheng Zubiao;Dong Zhaoying;Chu Xinyue;Chen Fangyuan;Han Bingbing(College of Chemistry and Chemical Engineering,Huangshan University,Huangshan 245041,China)

机构地区：[1]黄山学院化学化工学院,安徽黄山245041

出　　处：《黄山学院学报》2021年第5期47-50,共4页Journal of Huangshan University

基　　金：安徽省大学生创新创业训练计划项目(S201910375091);安徽省教育厅教学研究项目(2020jyxm1756;KJHS2019B11)。

摘　　要：介绍了以二卤海因(二溴海因和二氯海因)为催化剂催化苯甲酸和甲醇反应制备苯甲酸甲酯的方法,分别探讨了催化剂二卤海因的用量、苯甲酸与甲醇的配比,反应温度以及时间等因素对甲酯化反应的影响,确定了最佳的反应条件为:20mol%的二卤海因;苯甲酸与甲醇的配比为1︰10~1︰20;反应温度60℃;反应时间7小时。在此条件下,苯甲酸甲酯收率为99%。同时底物拓展表明大部分苯甲酸甲酯类化合物收率均能达到95%以上。With DBDMH and DCDMH as catalysts, methyl benzoate is prepared from benzoic acid and methanol. The effects of the amount of DBDMH and DCDMH, the ratio of benzoic acid to methanol,reaction temperature and time on the methylation reaction were discussed. The optimum reaction conditions were determined as follows: It requires 20 mol% d DBDMH and DCDMH;The ratio of benzoic acid to methanol is 1 ∶ 10 ~ 1 ∶ 20;Reaction temperature is 60 ℃;The reaction time is 7 hours. Under these conditions, the yield of methyl benzoate is 99%. At the same time, the substrate expansion shows that the yield of most methyl benzoate compounds can reach more than 95%.

关 键 词：苯甲酸甲酯 酯化反应 二溴海因 二氯海因 机理 

分 类 号：TQ254.24[化学工程—有机化工]