T淋巴细胞亚群对鲍曼不动杆菌感染与定植的诊断价值  

Diagnostic Value of T Lymphocyte Subsets in Acinetobacter Baumannii Infection and Colonization

作　　者：刘婕妤 杨文杰[1] 赵学群[1] LIU Jie-yu;YANG Wen-jie;ZHAO Xue-qun(Department of Infection,Tianjin First Central Hospital,Tianjin 300000,China)

机构地区：[1]天津市第一中心医院感染科,天津300000

出　　处：《医学信息》2021年第20期167-169,共3页Journal of Medical Information

摘　　要：目的分析T淋巴细胞亚群对鲍曼不动杆菌(AB)感染与定植的鉴别诊断效果。方法选取2018年1月-2021年2月我院经痰培养分离出AB的80例患者作为研究对象,其中定植组45例,感染组35例,比较两组T淋巴细胞亚群水平,并分析AB感染与T淋巴细胞亚群水平的相关性及影响因素。结果两组CD3^(+)、CD4^(+)比较,差异无统计学意义(P>0.05);两组CD4^(+)/CD8^(+)、IL-2、IL-4、IL-17、TNF-α、IFN-γ比较,差异有统计学意义(P<0.05)。Spearman相关分析显示,AB感染与TNF-α、IFN-γ、IL-2、IL-4及IL-17呈正相关(r=0.302、0.243、0.305、0.259、0.495,P=0.011、0.018、0.009、0.008、0.000),与CD4^(+)/CD8^(+)呈负相关(r=-0.295,P=0.000)。多因素Logistic回归分析显示,CD4^(+)/CD8^(+)、IL-17以及IFN-γ是AB感染的高危因素。结论T淋巴细胞亚群在AB感染与定植中具有一定的参考价值,可作为临床鉴别诊断的重要指标。Objective To analyze the diagnostic value of T lymphocyte subsets in Acinetobacter baumannii(AB)infection and colonization.Methods A total of 80 patients with AB isolated by sputum culture in our hospital from January 2018 to February 2021 were selected as the research objects,including 45 patients in the colonization group and 35 patients in the infection group.The levels of T lymphocyte subsets in the two groups were compared,and the correlation between AB infection and T lymphocyte subsets and its influencing factors were analyzed.Results There was no significant difference in CD3^(+)and CD4^(+)between the two groups(P>0.05),there were statistically significant differences in CD4^(+)/CD8^(+),IL-2,IL-4,IL-17,TNF-αand IFN-γbetween the two groups(P<0.05).Spearman correlation analysis showed that AB infection was positively correlated with TNF-α,IFN-γ,IL-2,IL-4 and IL-17(r=0.302,0.243,0.305,0.259,0.495,P=0.011,0.018,0.009,0.008,0.000),and negatively correlated with CD4^(+)/CD8^(+)(r=-0.295,P=0.000).Multivariate logistic regression analysis showed that CD4^(+)/CD8^(+),IL-17 and IFN-γwere high risk factors for AB infection.Conclusion T lymphocyte subsets have a certain reference value in AB infection and colonization,which can be used as an important indicator for clinical differential diagnosis.

关 键 词：T淋巴细胞亚群 鲍曼不动杆菌 获得性肺炎 

分 类 号：R446.5[医药卫生—诊断学]